Synthesis of a mannose heptasaccharide of the pathogenic yeast, Candida glabrata IFO 0622 strain
文献类型：期刊论文
| 作者 | Zeng, YL; Zhang, TJ; Kong, FZ |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2002 |
| 卷号 | 337期号:15页码:1367-1371 |
| 关键词 | Mannose Oligosaccharides Trichloroacetimidates Regio- And Stereoselective Synthesis |
| DOI | 10.1016/S0008-6215(02)00162-3 |
| 英文摘要 | An effective synthesis of the mannose heptasaccharide existing in the pathogenic yeast, Candida glabrata IFO 0622 strain was achieved via TMSOTf-promoted condensation of a tetrasaccharide donor 13 with a trisaccharide acceptor 16, followed by deprotection. The tetrasaccharide 13 was constructed by coupling of 2,3,4,6-tetra-O-benzoyl-alpha-D-mannopyranosyl-(1 --> 3)-2,4,6-tri-O-acetyl-alpha-D-mannopyranosyl trichloroacetimidate (7) with allyl 3,4,6-tri-O-benzoyl-alpha-D-mannopyranosyl-(1 --> 2)-3,4,6-tri-O-benzoyl-alpha-D-mannopyranoside (10), followed by deallylation and trichloroacetimadation. The trisaccharide 16 was obtained by coupling of 6-O-acetyl-2,3,4-tri-O-benzoyl-alpha-D-mannopyranosyl trichloroacetimidate with 10, and subsequent 6-O-deacetylation. The disaccharide 7 was prepared through coupling of perbenzoylated mannosyl trichloroacetimidate with 4,6-O-benzylidene-1,2-O-ethylidene-beta-D-mannopyranose, then simultaneous debenzylidenation and deethylidenation, and subsequent acetylation, selective 1-O-deacetylation, and trichloroacetimidation. The disaccharide 10 was obtained by self-condensation of 3,4,6-tri-O-benzoyl-1,2-O-allyloxyethylidene-beta-D-mannopyranose, followed by selective 2-O-deacetylation. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000177924100004 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23969]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zeng, YL,Zhang, TJ,Kong, FZ. Synthesis of a mannose heptasaccharide of the pathogenic yeast, Candida glabrata IFO 0622 strain[J]. CARBOHYDRATE RESEARCH,2002,337(15):1367-1371. |
| APA | Zeng, YL,Zhang, TJ,&Kong, FZ.(2002).Synthesis of a mannose heptasaccharide of the pathogenic yeast, Candida glabrata IFO 0622 strain.CARBOHYDRATE RESEARCH,337(15),1367-1371. |
| MLA | Zeng, YL,et al."Synthesis of a mannose heptasaccharide of the pathogenic yeast, Candida glabrata IFO 0622 strain".CARBOHYDRATE RESEARCH 337.15(2002):1367-1371. |
入库方式： OAI收割
来源：生态环境研究中心
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