Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1
文献类型：期刊论文
| 作者 | Schnittger, Arp; Dissmeyer, Nico; Weimer, Annika K.; Pusch, Stefan; De Schutter, Kristof; Kamei, Claire Lessa Alvim; Nowack, Moritz K.; Novak, Bela; Duan, Gui-Lan; Zhu, Yong-Guan |
| 刊名 | PLANT CELL
 |
| 出版日期 | 2009-11 |
| 卷号 | 21期号:11页码:3641-3654 |
| 英文摘要 | Entry into mitosis is universally controlled by cyclin-dependent kinases (CDKs). A key regulatory event in metazoans and fission yeast is CDK activation by the removal of inhibitory phosphate groups in the ATP binding pocket catalyzed by Cdc25 phosphatases. In contrast with other multicellular organisms, we show here that in the flowering plant Arabidopsis thaliana, cell cycle control does not depend on sudden changes in the phosphorylation pattern of the PSTAIRE-containing Cdk1 homolog CDKA;1. Consistently, we found that neither mutants in a previously identified CDC25 candidate gene nor plants in which it is overexpressed display cell cycle defects. Inhibitory phosphorylation of CDKs is also the key event in metazoans to arrest cell cycle progression upon DNA damage. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1. These observations reveal a surprising degree of divergence in the circuitry of highly conserved core cell cycle regulators in multicellular organisms. Based on biomathematical simulations, we propose a plant-specific model of how progression through the cell cycle could be wired in Arabidopsis. |
| WOS记录号 | WOS:000273235600020 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21781]  |
| 专题 | 生态环境研究中心_土壤环境科学实验室 |
| 推荐引用方式 GB/T 7714 | Schnittger, Arp,Dissmeyer, Nico,Weimer, Annika K.,et al. Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1[J]. PLANT CELL,2009,21(11):3641-3654. |
| APA | Schnittger, Arp.,Dissmeyer, Nico.,Weimer, Annika K..,Pusch, Stefan.,De Schutter, Kristof.,...&De Veylder, Lieven.(2009).Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1.PLANT CELL,21(11),3641-3654. |
| MLA | Schnittger, Arp,et al."Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1".PLANT CELL 21.11(2009):3641-3654. |
入库方式： OAI收割
来源：生态环境研究中心
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