In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik
文献类型：期刊论文
| 作者 | Huang, Zheng-ming; Yang, Xin-bo; Wu, Lin-lin; Wu, Guang-xia; Liu, He-zhi |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2007-03 |
| 卷号 | 28期号:3页码:404-409 |
| 关键词 | Hyperoside Hepatitis b Virus Duck Hepatitis b Virus Antiviral Agents |
| 英文摘要 | Aim: To assess the anti-hepatitis B virus (HBV) effect of hyperoside extracted from Abelmoschus manihot (L) medik. Methods: The human hepatoma Hep G2.2.15 cell culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo and in vitro models to evaluate the anti-HBV effects. Results: In the cell model, the 50% toxic concentration of hyperoside was 0.115 g/L; the maximum nontoxic concentration was 0.05 g/L. On the maximum nontoxic concentrations, the inhibition rates of hyperoside on HBeAg and HBsAg in the 2.2.15 cells were 86.41% and 82.27% on d 8, respectively. In the DHBV infection model, the DHBV-DNA levels decreased significantly in the treatment of 0.05 g- kg(-1).d(-1) and 0.10 g.kg(-1).d(-1) dosage groups of hyperoside (P < 0.01). The inhibition of the peak of viremia was at the maximum at the dose of 0.10 g-kg(-1).d(-1) and reached 60.79% on d 10 and 69.78% on d 13, respectively. Conclusion: These results suggested that hyperoside is a strong inhibitor of HBsAg and HBeAg secretion in 2.2.15 cells and DHBV-DNA levels in the HBV-infected duck model. |
| WOS记录号 | WOS:000244418000013 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22613]  |
| 专题 | 生态环境研究中心_水污染控制实验室 |
| 推荐引用方式 GB/T 7714 | Huang, Zheng-ming,Yang, Xin-bo,Wu, Lin-lin,et al. In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik[J]. ACTA PHARMACOLOGICA SINICA,2007,28(3):404-409. |
| APA | Huang, Zheng-ming,Yang, Xin-bo,Wu, Lin-lin,Wu, Guang-xia,&Liu, He-zhi.(2007).In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik.ACTA PHARMACOLOGICA SINICA,28(3),404-409. |
| MLA | Huang, Zheng-ming,et al."In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik".ACTA PHARMACOLOGICA SINICA 28.3(2007):404-409. |
入库方式： OAI收割
来源：生态环境研究中心
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