Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation
文献类型：期刊论文
| 作者 | Chang, Jin; Wang, Huili; Guo, Baoyuan; Yin, Jing; Zhu, Feilong; Hao, Weiyu; Xu, Qi |
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 109期号:0页码:735-745 |
| 关键词 | Acylamino Acid Chiral Fungicides Chiral Center Lambda Dna Dna Methylation Enantioselectivity Toxiciepigenetics |
| 英文摘要 | Acylamino acid chiral fungicides (AACFs) are low-toxicity pesticides and considered as non-carcinogenic chemicals to laboratory animals. Though AACFs have potential toxicological effects on mammals by nongenotoxic mechanisms, the toxicoepigenomics of AACF5 has not been documented. In this article, we explored toxiciepigenetics of metalaxyl, benalaxyl and furalaxyl through epigenetics research on lambda DNA under different concentration exposure. The toxicoepigenomic difference of stereoisomers was examined also. Our results showed that AACFs would affect methyltransferase activity resulting in modulating DNA methylation levels and pattern. The LOAEL of R-metalaxyl and S-metalaxyl were 30 mM and 0.3 mM, respectively. The LOAEL of (R, S)-benalaxyl and (R, S)-furalaxyl were 0.3 Mm and 30 mM, respectively. A significant dose-response effect between (R, S)-benalaxyl and global methylation level was observed. Global methylation level was more susceptible to S-enantiomer compared to R-enantiomer, which indicated enantiomers of AACFs have the enantioselectivity in toxiciepigenetics. Moreover, the dependence of the methylation inhibition on the chiral center of metalaxyl may suggest a considerable specificity of the compound of AACF5 for DNA methyltransferases. The inhibition effect between Renantiomer and S-enantiomer of AACFs on DNA methylation levels generated in this study is important for low-toxicity pesticides toxicoepigenomics evaluation. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39610]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Chang, Jin,Wang, Huili,Guo, Baoyuan,et al. Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation[J]. FOOD AND CHEMICAL TOXICOLOGY,2017,109(0):735-745. |
| APA | Chang, Jin.,Wang, Huili.,Guo, Baoyuan.,Yin, Jing.,Zhu, Feilong.,...&Xu, Qi.(2017).Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation.FOOD AND CHEMICAL TOXICOLOGY,109(0),735-745. |
| MLA | Chang, Jin,et al."Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation".FOOD AND CHEMICAL TOXICOLOGY 109.0(2017):735-745. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。