Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers
文献类型：期刊论文
| 作者 | Li, Wei; Li, Jitong; Wang, Huili; Li, Jianzhong; Guo, Baoyuan; Chang, Jing |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 171期号:0页码:554-563 |
| 关键词 | Triadimefon Eremias Argus Sex Steroid Hormones 17-beta-hydroxysteroid Steroid Hormone Receptors Cytochrome P450 Enzymes |
| 英文摘要 | Triadimefon (TF) is a widely used chiral fungicide with one chiral centre and two enantiomers (TF1 and TF2). However, little is reported about the ecological toxicity of reptiles on an enantioselective level. TF is a potential endocrine disruptor that may interfere with sex steroid hormones, such as testosterone (T) and 17beta-estradiol (E-2). In our study, the lizards Mongolia Racerunner (Eremias argus) were orally exposed to TF and its enantiomers for 21 days. Plasma sex steroid hormones and steroidogenic-related genes, including 17-beta-hydroxysteroid (hsd17 beta), cytochrome P450 enzymes (cyp19 and cyp17), and steroid hormone receptors (era and Ar) were evaluated. After exposure, the plasma testosterone level in the 100 mg/kg(bw) group was elevated, while the oestradiol level was reduced. This phenomenon may be caused by the transformation of cyp19, which may inhibit the conversion of testosterone to oestradiol and affect sexual behaviour. In addition, the two enantiomers have different effects on hormone levels, which testified to the previously reported biotoxic dissimilarity between TF1 and TF2 in organisms. Furthermore, the cyp19 mRNA level in liver and gonad of the TF2 and TF group (100 mg/kg(bw) were significantly down-regulated, while the cyp17 and hsd17 beta mRNA levels were up-regulated. The expression of era and Ar mRNA levels were up-regulated in males but not in females, which may indicate that TF has sex differences on these two genes. As seen from the above results, TF and its enantiomers may have endocrine-disrupting effects on lizards (E. argus) by acting sensitively on sex steroid hormones and steroidogenic-related genes. (C) 2016 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39617]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Wei,Li, Jitong,Wang, Huili,et al. Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers[J]. CHEMOSPHERE,2017,171(0):554-563. |
| APA | Li, Wei,Li, Jitong,Wang, Huili,Li, Jianzhong,Guo, Baoyuan,&Chang, Jing.(2017).Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers.CHEMOSPHERE,171(0),554-563. |
| MLA | Li, Wei,et al."Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers".CHEMOSPHERE 171.0(2017):554-563. |
入库方式： OAI收割
来源：生态环境研究中心
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