Enantioselective metabolism of triadimefon and its chiral metabolite triadimenol in lizards
文献类型：期刊论文
| 作者 | Shen, Qiuxuan; Wang, Yinghuan; Zhuang, Guoqiang; Li, Wei; Xu, Peng; Li, Jitong |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 143期号:0页码:159-165 |
| 关键词 | Eremias Argus Enantioselectivity Triadimefon Triadimenol |
| 英文摘要 | Chinese lizards (Eremias argus) were exposed to separated R-(-)-triadimefon, S-(+)-triadimefon and racemic triadimefon to evaluate enantioselective accumulation of triadimefon. After single oral administration of R(-)-triadimefon, S-(+)-triadimefon and racemic triadimefon, the time-concentration curves in different tissues were found to be different. Triadimefon enantiomers crossed the blood-brain barrier and brain is a main target organ. The residues of triadimefon enantiomers in fat were highest after 24 h indicating that fat was the main tissue of accumulation. In racemic triadimefon exposure group, the enantiomer fractions of R-(-)-triadimefon in different tissues showed that the differences between R-(-)-triadimefon and S-(+)-triadimefon were significant in absorption and metabolism, but the differences became smaller in exclusion and accumulation. From the results of mathematical models, S-(+)-triadimefon was absorbed and eliminated faster than R-(-)-triadimefon, and R-(-)-triadimefon was easily distributed in the tissues and more easily converted into its metabolites. Furthermore, among the four enantiomers of triadimenol, SR-(-)-triadimenol produced by S-(+)-triadimefon may have the highest fungicidal activity and the strongest biological toxicity, RR-(+)-triadimenol produced by R-(-)-triadimefon was most likely to bioaccumulate in lizard. Identifying toxicological effects and dose-response relationship of SR-(-)-triadimenol and RR-(+)-triadimenol will help fully assess the risk of TF enantiomers use in the future. The results enrich and supplement the knowledge of the environmental fate of triadimefon enantiomers. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39628]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Shen, Qiuxuan,Wang, Yinghuan,Zhuang, Guoqiang,et al. Enantioselective metabolism of triadimefon and its chiral metabolite triadimenol in lizards[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2017,143(0):159-165. |
| APA | Shen, Qiuxuan,Wang, Yinghuan,Zhuang, Guoqiang,Li, Wei,Xu, Peng,&Li, Jitong.(2017).Enantioselective metabolism of triadimefon and its chiral metabolite triadimenol in lizards.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,143(0),159-165. |
| MLA | Shen, Qiuxuan,et al."Enantioselective metabolism of triadimefon and its chiral metabolite triadimenol in lizards".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 143.0(2017):159-165. |
入库方式： OAI收割
来源：生态环境研究中心
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