Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages
文献类型：期刊论文
| 作者 | Li, Wei; Chang, Jing; Guo, Baoyuan; Xu, Peng; Wang, Yinghuan; Li, Jianzhong; Wang, Huili |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 172期号:0页码:210-216 |
| 关键词 | Lizard Thyroid Hormone Flufenoxuron Proliferation Phase Resting Phase |
| 英文摘要 | Flufenoxuron is a widely used pesticide to inhibit the synthesis of chitin during insect development and its effect on the growth of lizards has been little addressed. The hypothalamus-pituitary-thyroid (HPT) axis plays an important role on the development of lizards. In this study, the lizards at different development stages (proliferation and resting stages) were exposed to flufenoxuron for 21 days. The plasma thyroid hormone levels, thyroid gland histopathology and expression profiles of thyroid hormone receptors (tr alpha, tr beta), deiodinases (diol, dio2), and transthyretin (ttr) genes were measured to evaluated the toxic effect of flufenoxuron on the HPT axis at different stages. The flufenoxuron exposure showed more seriously effect on the triiodothyronine (T3) level at resting phase than that at proliferation stage. The follicle epithelium cell height in the thyroid was only significantly increased when the exposed male lizards were at proliferation stage. The alteration of HPT axis-related genes expression was gender and tissue dependent after flufenoxuron treatment. The lizards exposed to flufenoxuron showed that the tra, tr beta, diol, dio2, and ttr genes in the female liver were more sensitive at the proliferation stage than that at the resting stage. In the male brain, the expressions of tra, tr beta, diol, and dio2 gene were significant decreased at proliferation stage while significant increased at resting stage after flufenoxuron exposure. Therefore, the thyroid endocrine system of lizards could be affected by the flufenoxuron exposure and the different development stage should also be considered when study the toxic effect of contaminants on the lizards. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39659]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Wei,Chang, Jing,Guo, Baoyuan,et al. Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages[J]. CHEMOSPHERE,2017,172(0):210-216. |
| APA | Li, Wei.,Chang, Jing.,Guo, Baoyuan.,Xu, Peng.,Wang, Yinghuan.,...&Wang, Huili.(2017).Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages.CHEMOSPHERE,172(0),210-216. |
| MLA | Li, Wei,et al."Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages".CHEMOSPHERE 172.0(2017):210-216. |
入库方式： OAI收割
来源：生态环境研究中心
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