Facilitating Translational Nanomedicine via Predictive Safety Assessment
文献类型：期刊论文
| 作者 | Mirshafiee, Vahid; Jiang, Wen; Sun, Bingbing; Wang, Xiang; Xia, Tian |
| 刊名 | MOLECULAR THERAPY
 |
| 出版日期 | 2017-07-05 |
| 卷号 | 25期号:7页码:1522-1530 |
| 英文摘要 | Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39466]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 推荐引用方式 GB/T 7714 | Mirshafiee, Vahid,Jiang, Wen,Sun, Bingbing,et al. Facilitating Translational Nanomedicine via Predictive Safety Assessment[J]. MOLECULAR THERAPY,2017,25(7):1522-1530. |
| APA | Mirshafiee, Vahid,Jiang, Wen,Sun, Bingbing,Wang, Xiang,&Xia, Tian.(2017).Facilitating Translational Nanomedicine via Predictive Safety Assessment.MOLECULAR THERAPY,25(7),1522-1530. |
| MLA | Mirshafiee, Vahid,et al."Facilitating Translational Nanomedicine via Predictive Safety Assessment".MOLECULAR THERAPY 25.7(2017):1522-1530. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。