Benzo(a)pyrene-induced a mitochondria-independent apoptosis of liver in juvenile Chinese rare minnows (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Zha, Jinmiao; Rao, Haiou; Yuan, Lilai; Wang, Zijian; Kumaran, Satyanarayanan Senthil; Hong, Xiangsheng |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 231期号:0页码:191-199 |
| 关键词 | Benzo(a)Pyrene Chinese Rare Minnow (Gobiocypris Rarus) Histopathology Apoptosis Mitochondrial Pathway |
| 英文摘要 | To examine the effects of BaP on tissue apoptosis, laboratory studies were conducted using juvenile Chinese rare minnows (Gobiocypris rarus) exposed to 1, 5, 20, and 80 mu g/L of BaP for 28 days. The post-treatment pathological findings in the liver were associated with hepatocyte swelling, karyopyknosis, and karyorrhexis. Moreover, an increase in the goblet cells in the intestine, epithelial hyperplasia of the gills and fusion of gill lamellae were observed. Significant increases in hepatocyte apoptosis using the TUNEL stain were observed in the liver tissue but not in the intestine and gills. In addition, BaP exposure significantly up-regulated the mRNA levels of cyp1a1, p53, bax, bcl-2, and caspase-9 in the liver following the 5, 20, and 80 mu g/L treatments, whereas the apaf-1 was significantly down-regulated following all treatments. Moreover, the activities of caspase 3 and caspase 8 were markedly elevated, whereas the protein expression levels of Apaf-1 were down-regulated following the 20 and 80 mu g/L treatments. Taken together, our results suggested that BaP strongly induces tissue-specific apoptosis in vivo, leading to significant pathological changes. The responsiveness of apoptotic-related genes demonstrates that BaP induced apoptosis in the liver may be through a mitochondria-independent pathway. (C) 2017 Published by Elsevier Ltd. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39670]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zha, Jinmiao,Rao, Haiou,Yuan, Lilai,et al. Benzo(a)pyrene-induced a mitochondria-independent apoptosis of liver in juvenile Chinese rare minnows (Gobiocypris rarus)[J]. ENVIRONMENTAL POLLUTION,2017,231(0):191-199. |
| APA | Zha, Jinmiao,Rao, Haiou,Yuan, Lilai,Wang, Zijian,Kumaran, Satyanarayanan Senthil,&Hong, Xiangsheng.(2017).Benzo(a)pyrene-induced a mitochondria-independent apoptosis of liver in juvenile Chinese rare minnows (Gobiocypris rarus).ENVIRONMENTAL POLLUTION,231(0),191-199. |
| MLA | Zha, Jinmiao,et al."Benzo(a)pyrene-induced a mitochondria-independent apoptosis of liver in juvenile Chinese rare minnows (Gobiocypris rarus)".ENVIRONMENTAL POLLUTION 231.0(2017):191-199. |
入库方式： OAI收割
来源：生态环境研究中心
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