Enhanced Oxidation of Tetracycline by Permanganate via the Alkali-Induced Alteration of the Highest Occupied Molecular Orbital and the Electrostatic Potential
文献类型：期刊论文
| 作者 | Song, Dean; Cheng, Hanyang; Liu, Ruiping; Qiang, Zhimin; He, Hong; Liu, Huijuan; Qu, Jiuhui |
| 刊名 | INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
 |
| 出版日期 | 2017-04-26 |
| 卷号 | 56期号:16页码:4703-4708 |
| 英文摘要 | The reaction between tetracycline and alkaline permanganate was investigated by combining experimental and computational methods. The kinetics was initially studied using a stopped-flow technique and was found to be first-order in tetracycline and permanganate. The second-order rate constant was positive linearly dependent on the concentration of hydroxyl ion (0.01-0.10 M), indicating the presence of base catalysis. By construction of the Eyring plots in the range of 293-308 K, a lower activation barrier ((14.89 +/- 0.44) kcal mol(-1)) was obtained at 298 K for the base-catalyzed pathway compared with that ((17.72 +/- 1.84) kcal mol(-1)) for the uncatalyzed pathway. The effect of ionic strength further suggested the existence of a complex with higher charge and reactivity. It is confirmed by the theoretical analysis that the hydroxyl ion could attract the proton of tetracycline toward itself to form a complex-like structure with a highly reactive phenolate-type moiety. The highest occupied molecular orbital of tetracycline was then transformed from double bond to aromatic ring. The result is supported by the product analysis that the initial oxidation of tetracycline by permanganate occurred predominantly at phenolic group in an alkaline aqueous solution. The base-catalyzed effect was finally explained by electrostatic potential that hydroxyl ion was able to increase the negative charge of tetracycline, making its phenolic group a more electron rich moiety for electrophilic attack. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39694]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Song, Dean,Cheng, Hanyang,Liu, Ruiping,et al. Enhanced Oxidation of Tetracycline by Permanganate via the Alkali-Induced Alteration of the Highest Occupied Molecular Orbital and the Electrostatic Potential[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2017,56(16):4703-4708. |
| APA | Song, Dean.,Cheng, Hanyang.,Liu, Ruiping.,Qiang, Zhimin.,He, Hong.,...&Qu, Jiuhui.(2017).Enhanced Oxidation of Tetracycline by Permanganate via the Alkali-Induced Alteration of the Highest Occupied Molecular Orbital and the Electrostatic Potential.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,56(16),4703-4708. |
| MLA | Song, Dean,et al."Enhanced Oxidation of Tetracycline by Permanganate via the Alkali-Induced Alteration of the Highest Occupied Molecular Orbital and the Electrostatic Potential".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 56.16(2017):4703-4708. |
入库方式： OAI收割
来源：生态环境研究中心
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