Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea)
文献类型：期刊论文
| 作者 | Yan, Saihong; Wu, Huimin; Qin, Jianhui; Zha, Jinmiao; Wang, Zijian |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 225期号:0页码:559-568 |
| 关键词 | Tbep Tbp C. Fluminea Oxidative Stress Multixenobiotic Resistance |
| 英文摘要 | Halogen-free organophosphorus flame retardants are widespread in aquatic environments. Although it has been documented that they affect the behavior and reproduction of aquatic species, researches investigating cellular detoxification and the defense system in bivalves are scarce. In this study, adult Asian clams (C. fluminea) were exposed to tris (2-butoxyethyl) phosphate (TBEP) and tributyl phosphate (TBP) at 20, 200, and 2000 mu g/L for 28 d. The results showed no noticeable difference in siphoning behavior. However, the siphoning behavior displayed a trend toward a slight decrease in the treatment groups. GR activity was markedly reduced compared with the control groups, whereas the levels of cyp4 significantly increased following the 2000 mu g/L TBP treatments (p < 0.05). Moreover, the levels of gstsl and gstml significantly decreased following all TBEP treatments and were significantly inhibited by 20 mu g/L TBP (p < 0.05). The adverse effects on antioxidant enzymes suggested that C. fluminea mainly relies on the antioxidant system to reduce damage without an increase in MDA levels following exposure to a low concentration. Moreover, mRNA expression levels of heat shock proteins (hsp 22, 40, 60, 70, and 90) were significantly down-regulated with TBEP and TBP treatments lower than 200 mu g/L (p < 0.05), whereas significant up-regulations were observed for hsp 22 and hsp 70 in response to 2000 mu g/L TBP treatment (p < 0.05). Up-regulation of ATP-binding cassette (ABC) transporter genes (abcbl and abccl) showed that TBEP and TBP could activate the multixenobiotic resistance (MXR) system to discharge xenobiotics in C fluminea, which kept its shell closed at high concentrations to prevent xenobiotic entry. Our results provide a new insight into the different mechanisms of cellular detoxification and the MXR system of C fluminea in response to low and high concentrations of TBEP and TBP. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39705]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Yan, Saihong,Wu, Huimin,Qin, Jianhui,et al. Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea)[J]. ENVIRONMENTAL POLLUTION,2017,225(0):559-568. |
| APA | Yan, Saihong,Wu, Huimin,Qin, Jianhui,Zha, Jinmiao,&Wang, Zijian.(2017).Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea).ENVIRONMENTAL POLLUTION,225(0),559-568. |
| MLA | Yan, Saihong,et al."Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea)".ENVIRONMENTAL POLLUTION 225.0(2017):559-568. |
入库方式： OAI收割
来源：生态环境研究中心
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