A conducive bioceramic/polymer composite biomaterial for diabetic wound healing
文献类型：期刊论文
| 作者 | Lv, Fang1; Wang, Jie3; Xu, Peng1; Han, Yiming1; Ma, Hongshi2; Xu, He3; Chen, Shijie1; Chang, Jiang2; Ke, Qinfei3; Liu, Mingyao1 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2017 |
| 卷号 | 60页码:128 |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2017.07.020 |
| 英文摘要 | Diabetic wound is a common complication of diabetes. Biomaterials offer great promise in inducing tissue regeneration for chronic wound healing. Herein, we reported a conducive Poly (caprolactone) (PCL)/ gelatin nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) for diabetic wound healing. NAGEL bioceramic particles were well distributed in the inner of PCL/gelatin nanofibers via co-electrospinning process and the Si ions maintained a sustained release from the composite scaffolds during the degradation process. The nanofibrous scaffolds significantly promoted the adhesion, proliferation and migration of human umbilical vein endothelial cells (HUVECs) and human keratinocytes (HaCaTs) in vitro. The in vivo study demonstrated that the scaffolds distinctly induced the angiogenesis, collagen deposition and re-epithelialization in the wound sites of diabetic mice model, as well as inhibited inflammation reaction. The mechanism for nanofibrous composite scaffolds accelerating diabetic wound healing is related to the activation of epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT) pathway in vivo and in vitro. Our results suggest that the released Si ions and nanofibrous structure of scaffolds have a synergetic effect on the improved efficiency of diabetic wound healing, paving the way to design functional biomaterials for tissue engineering and wound healing applications. Statement of Significance In order to stimulate tissue regeneration for chronic wound healing, a new kind of conducive nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) were prepared via co-electrospinning process. Biological assessments revealed that the NAGEL bioceramic particles could active epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT) pathway in vitro and in vivo. The new composite scaffold had potential as functional biomaterials for tissue engineering and wound healing applications. The strategy of introducing controllable amount of therapeutic ions instead of loading expensive drugs/growth factors on nanofibrous composite scaffold provides new options for bioactive biomaterials. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000411421400010 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26645]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 2.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 4.Shanghai Normal Univ, Coll Life & Environm Sci, 100 Guilin Rd, Shanghai 200234, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Fang,Wang, Jie,Xu, Peng,et al. A conducive bioceramic/polymer composite biomaterial for diabetic wound healing[J]. ACTA BIOMATERIALIA,2017,60:128. |
| APA | Lv, Fang.,Wang, Jie.,Xu, Peng.,Han, Yiming.,Ma, Hongshi.,...&Wu, Chengtie.(2017).A conducive bioceramic/polymer composite biomaterial for diabetic wound healing.ACTA BIOMATERIALIA,60,128. |
| MLA | Lv, Fang,et al."A conducive bioceramic/polymer composite biomaterial for diabetic wound healing".ACTA BIOMATERIALIA 60(2017):128. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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