A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection
文献类型：期刊论文
| 作者 | Wang, Jiaxing; Zhou, Huaijuan1; Guo, Geyong; Cheng, Tao; Peng, Xiaochun; Mao, Xin; Li, Jinhua1,2,3; Zhang, Xianlong |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 12页码:3121 |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S129459 |
| 英文摘要 | Bloodstream infection, especially with implants involved, is an often life-threatening condition with high mortality rates, imposing a heavy burden on patients and medical systems. Herein, we firstly deposited homogeneous vanadium metal, V2O3, VO2, and V2O5 nanofilms on quartz glass by magnetron sputtering. Using these platforms, we further investigated the potential antimicrobial efficiency of these nano-VOx films and the interactions of human erythrocytes and bacteria ( methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa) with our samples in a novel cell-bacteria coculture model. It was demonstrated that these nano-VOx precipitated favorable antibacterial activity on both bacteria, especially on S. aureus, and this effect increased with higher vanadium valence. A possible mechanism accountable for these results might be elevated levels of vanadium-induced intracellular reactive oxygen species. More importantly, based on hemolysis assays, our nano-VOx films were found to be able to kill prokaryotic cells but were not toxic to mammalian cells, holding the potential for the prevention of implant-related hematogenous infections. As far as we know, this is the first report wherein such nano-VOx films have assisted human erythrocytes to combat bacteria in a valence-dependent manner. Additionally, vanadium ions were released from these nano-VOx films in a sustained manner, and low-valence films possessed better biocompatibility with human fibroblasts. This work may provide new insights for biomedical applications of inorganic vanadium compounds and attract growing attention in this field. From the perspective of surface modification and functionalization, this study holds promise to avail the prophylaxis of bloodstream infections involving implantable biomedical devices. |
| WOS记录号 | WOS:000399791700001 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/26690]  |
| 专题 | 中国科学院上海硅酸盐研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthopaed, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai, Peoples R China 3.Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiaxing,Zhou, Huaijuan,Guo, Geyong,et al. A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:3121. |
| APA | Wang, Jiaxing.,Zhou, Huaijuan.,Guo, Geyong.,Cheng, Tao.,Peng, Xiaochun.,...&Zhang, Xianlong.(2017).A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,3121. |
| MLA | Wang, Jiaxing,et al."A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):3121. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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