Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders.
文献类型：期刊论文
| 作者 | Zhou, Zhifeng; Gan, Yungen; Hu, Qingmao; Xu, Jinping; Wang, Hongwei; Zhang, Lu; Xu, Ziyun; Li, Tian; Zhou, Zhenhui |
| 刊名 | FRONTIERS IN NEUROSCIENCE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Some studies identified hypo-connectivity, while others showed hyper-connectivity of the insula in the autism spectrum disorders (ASD). These contradictory findings leave open the question of whether and to what extent functional connectivity of the insula is altered and how functional connectivity of the insula is associated with the severity of ASD. A newly emerging insular atlas that comprises multiple functionally differentiated subregions provides a new framework to interpret the functional significance of insular findings and uncover the mechanisms underlying the severity of ASD. Using the new insularatlas, the present study aimed to investigate the distinct functional connectivity of the insular subregions and their associations with ASD severity in a cohort of 49 children with ASD and 33 typically developing (TD) subjects. We found that compared with TD group, the ASD group showed different connectivity patterns in the left ventral agranular insula, right ventral dysgranular and granular insula, and dorsal dysgranular insula, characterized by significant hyper-connectivity and/or hypo-connectivity with special brain regions. Furthermore, both the hypo-connectivity and hyper-connectivity patterns of the insularsubregions were significantly associated with the severity of ASD symptoms. Our research demonstrated distinct functional connectivity patterns of theinsular subregions and emphasized the importance of the subdivisions within the insula to the potential impact of functional difference in children with ASD. Moreover, these results might help us to better understand the mechanisms underlying the symptoms in children with ASD and might elucidate potential biomarkers for clinical applications. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14198]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Zhou, Zhifeng,Gan, Yungen,Hu, Qingmao,et al. Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders.[J]. FRONTIERS IN NEUROSCIENCE,2018. |
| APA | Zhou, Zhifeng.,Gan, Yungen.,Hu, Qingmao.,Xu, Jinping.,Wang, Hongwei.,...&Zhou, Zhenhui.(2018).Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders..FRONTIERS IN NEUROSCIENCE. |
| MLA | Zhou, Zhifeng,et al."Both Hypo-Connectivity and Hyper-Connectivity of the Insular Subregions Associated With Severity in Children With Autism Spectrum Disorders.".FRONTIERS IN NEUROSCIENCE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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