GeneFuse: detection and visualization of target gene fusions from DNA sequencing data
文献类型：期刊论文
| 作者 | Jia Gu; Shifu Chen; Ming Liu; Tanxiao Huang; Wenting Liao; Mingyan Xu |
| 刊名 | International Journal of Biological Sciences
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In recent years, gene fusion detection for cancer treatment has become increasingly important since more therapeutic agents have been developed to suppress fusion kinases. Although a number of tools have been developed to detect gene fusions from DNA sequencing data, most of them are not sensitive enough for processing the data from the samples with low tumor DNA composition, like cell-free tumor DNA. In this paper, we will introduce GeneFuse, a tool to detect and visualize gene fusions with high sensitivity and specificity. GeneFuse focuses on the curated gene fusions, which are available in COSMIC (the Catalogue of Somatic Mutations in Cancer) database. For each detected fusion, GeneFuse reports its genome locus, inferred protein forms, and supporting sequencing reads. The fusion detection results are visualized in an HTML page for cloud-friendly validation. GeneFuse is an open source tool available at GitHub: https://github.com/OpenGene/GeneFuse |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14241]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Jia Gu,Shifu Chen,Ming Liu,et al. GeneFuse: detection and visualization of target gene fusions from DNA sequencing data[J]. International Journal of Biological Sciences,2018. |
| APA | Jia Gu,Shifu Chen,Ming Liu,Tanxiao Huang,Wenting Liao,&Mingyan Xu.(2018).GeneFuse: detection and visualization of target gene fusions from DNA sequencing data.International Journal of Biological Sciences. |
| MLA | Jia Gu,et al."GeneFuse: detection and visualization of target gene fusions from DNA sequencing data".International Journal of Biological Sciences (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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