Targeted next‐generation sequencing approach for moleculargenetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous
文献类型：期刊论文
| 作者 | Chen Xu; Dan Wang; Shengyun Liang; Xipeng Zhang; Subrata Kumar Dey; Yuwei Li; Yongjun Yu; Mingsen Li; Guoru Zhao; Zhao Zhang |
| 刊名 | MOLECULAR GENETICS & GENOMIC MEDICINE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease which primarily manifested with developing adenomas or polyps in colon or rectum. It is caused by the germline mutations in adenomatous polyposis coli (APC) gene. Patients with FAP are usually manifested with “hundreds or even thousands” adenomas or polyps in colon or rectum. However, without proper clinical diagnosis and timely surgical interventions, colorectal adenomas, or polyps gradually increase in size and in numbers which finally leads to colorectal cancer (CRC) at the mean age of 36 years of the patient. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14264]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Chen Xu,Dan Wang,Shengyun Liang,et al. Targeted next‐generation sequencing approach for moleculargenetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous[J]. MOLECULAR GENETICS & GENOMIC MEDICINE,2018. |
| APA | Chen Xu.,Dan Wang.,Shengyun Liang.,Xipeng Zhang.,Subrata Kumar Dey.,...&Zhao Zhang.(2018).Targeted next‐generation sequencing approach for moleculargenetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous.MOLECULAR GENETICS & GENOMIC MEDICINE. |
| MLA | Chen Xu,et al."Targeted next‐generation sequencing approach for moleculargenetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous".MOLECULAR GENETICS & GENOMIC MEDICINE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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