Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion.
文献类型：期刊论文
| 作者 | So, Kwok-Fai; Huang, Yubin; Xu, Zhen; Xiong, Shanshan; Sun, Fangfang; Qin, Guangrong; Hu, Guanglei; Wang, Jingjing; Zhao, Lei; Liang, Yu-Xiang |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived from microglial progenitor cells expressing nestin in the brain. However, the origin of these repopulatedmicroglia has been hotly debated. In this study, we investigated the origin of repopulated microglia by a series of fate-mapping approaches. We first excluded the blood origin of repopulated microglia via parabiosis. With different transgenic mouse lines, we then demonstrated that all repopulatedmicroglia were derived from the proliferation of the few surviving microglia (<1%). Despite a transient pattern of nestin expression in newly forming microglia, none of repopulated microglia were derived from nestin-positive non-microglial cells. In summary, we conclude that repopulated microglia aresolely derived from residual microglia rather than de novo progenitors, suggesting the absence of microglial progenitor cells in the adult brain. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14268]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | So, Kwok-Fai,Huang, Yubin,Xu, Zhen,et al. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion.[J]. NATURE NEUROSCIENCE,2018. |
| APA | So, Kwok-Fai.,Huang, Yubin.,Xu, Zhen.,Xiong, Shanshan.,Sun, Fangfang.,...&Peng, Bo.(2018).Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion..NATURE NEUROSCIENCE. |
| MLA | So, Kwok-Fai,et al."Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion.".NATURE NEUROSCIENCE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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