Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.
文献类型：期刊论文
| 作者 | So, Kwok-Fai; Peng, Bo; Rao, Yanxia; Huang, Yubin; Xu, Zhen; Xiong, Shanshan; Qin, Guangrong; Sun, Fangfang; Yang, Jian; Yuan, Ti-Fei |
| 刊名 | CELL DISCOVERY
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Elucidating the origin of microglia is crucial for understanding their functions and homeostasis. Previous study has indicated that Nestin-positive progenitor cells differentiate into microglia and replenish the brain after depleting most brain microglia. Microglia have also shown the capacity to repopulate the retina after eliminating all retinal microglia. However, the origin(s) of repopulated retinal microglia is/are unknown. In this study, we aim to investigate the originsof repopulated microglia in the retina. Interestingly, we find that repopulated retinal microglia are not derived from Nestin-positive progenitor cells. Instead, they have two origins: the center-emerging microglia are derived from residual microglia in the optic nerve and the periphery-emerging microglia are derived from macrophages in the ciliary body/iris. Therefore, we have for the first time identified the extra-retinal origins of microglia in the adult mammalian retina by using a model of microglial repopulation, which may shed light on the target exploration of therapeutic interventions for retinaldegenerative disorders. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14274]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | So, Kwok-Fai,Peng, Bo,Rao, Yanxia,et al. Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.[J]. CELL DISCOVERY,2018. |
| APA | So, Kwok-Fai.,Peng, Bo.,Rao, Yanxia.,Huang, Yubin.,Xu, Zhen.,...&Wu, Tianzhun.(2018).Dual extra-retinal origins of microglia in the model of retinal microglia repopulation..CELL DISCOVERY. |
| MLA | So, Kwok-Fai,et al."Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.".CELL DISCOVERY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。