Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.
文献类型：期刊论文
| 作者 | Qi, Qiaofang; Gao, Duyang; Wang, Yating; Li, Dongliang; Zheng, Hairong; Zhang, Xuanjun; Sheng, Zonghai; Yuan, Zhen; Chang, Kaiwen; Liu, Yubin |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, most photothermal agents are limited by their instability and low photothermal conversion efficiency. In this study, we report new conjugated polymer dots (Pdots) as multifunctional agents for photoacoustic (PA) imaging-guided PTT. The novel 4,8-bis [5-(2-ethylhexyl)thiophen-2-yl]-2,6-bis(trimethylstannyl)benzo [1,2-b:4,5-b']dithiophene-6,6'-dibromo-N,N'-(2-ethylhexyl)isoindigo (BDT-IID) Pdots are readily fabricated though nanoreprecipitation and can absorb strongly in the 650-700 nm region. Furthermore, the BDT-IID Pdots possess a stable nanostructure and an extremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%. More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offer concurrently enhanced PA contrast and sufficient photothermal effect. Consequently, the BDT-IID Pdots can be exploited as a unique theranostic nanoplatform for PA imaging-guided PTT of tumors, holding great promise for their clinical translational development. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14313]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Qi, Qiaofang,Gao, Duyang,Wang, Yating,et al. Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.[J]. ACS APPLIED MATERIALS & INTERFACES,2018. |
| APA | Qi, Qiaofang.,Gao, Duyang.,Wang, Yating.,Li, Dongliang.,Zheng, Hairong.,...&Hu, Dehong.(2018).Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy..ACS APPLIED MATERIALS & INTERFACES. |
| MLA | Qi, Qiaofang,et al."Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.".ACS APPLIED MATERIALS & INTERFACES (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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