Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy
文献类型：期刊论文
| 作者 | Xin Liu; Hairong Zheng; Xiaobing Wang; Yali Jia; Zonghai Sheng; Dehong Hu; Fei Yan; Mingting Zhu; Guanhui Gao; Pan Wang |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Liposome nanomedicine has been successfully applied for cancer chemotherapy in patients. However, in general, the therapeutic e ffi cacy is con fi ned by its limited accumulation and penetration in solid tumors. Here, we established a biomimetic strategy for the preparation of highly penetrative liposome nanomedicine for enhanced chemotherapeutic e ffi cacy. By applying this unique type of nano- medicine, membrane proteins on the cancer cells are used as highly penetrative targeting ligands. Biomimetic liposomes are highly stable, exhibiting a superior in vitro homologous targeting ability, and a 2.25-fold deeper penetration in 3D tumor spheroids when compared to conventional liposome nanomedicine. The fl uorescence/photoacoustic dual-modal imaging approach demonstrated enhanced tumor accumulation and improved tumor penetration of the biomimetic liposome in C6 glioma tumor-bearing nude mice. Following the intravenous administration of biomimetic lipo- some nanomedicine, the tumor inhibition rate reached up to 93.3%, which was signi fi cantly higher when compared to that of conventional liposome nanomedicine (69.3%). Moreover, histopathological analyses demonstrated that biomimetic liposome nanomedicine has limited side e ff ects. Therefore, these results suggested that a cancer cell membrane-based biomimetic strategy may provide a break- through approach for enhancing drug penetration and improving treatment e ffi cacy, holding a great promise for further clinical studies. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14330]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Xin Liu,Hairong Zheng,Xiaobing Wang,et al. Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy[J]. BIOMATERIALS SCIENCE ,2018. |
| APA | Xin Liu.,Hairong Zheng.,Xiaobing Wang.,Yali Jia.,Zonghai Sheng.,...&Pan Wang.(2018).Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy.BIOMATERIALS SCIENCE . |
| MLA | Xin Liu,et al."Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy".BIOMATERIALS SCIENCE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。