Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery
文献类型：期刊论文
| 作者 | Li, Yue; Yan, Fei; Zheng, Hairong; Yu, Jinsui; Chen, Zhiyi; Du, Meng |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
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| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | To attain attractive ultrasound-responsive gene delivery, a new kind of echogenic chitosan nanodroplets (CND) was developed to explore the potential to deliver genes in a spatiotemporally controlled manner. Self-assembled amphiphilic chitosan micelles of nanoscale size were fabricated to encapsulate hydrophobic perfluoropentane into the inner cores. The resulting CND presented a positive surface charge. enabling the formation of nano-complexes with genetic cargo through electrostatic interactions. Agarose-gel electrophoresis further confirmed the ability of CND to bind DNA. CND was also observed to protect DNA from degradation by nucleases. A temperature-dependent droplet-to-bubble conversion was also demonstrated. More importantly, our study revealed that CND in combination with ultrasound could significantly enhance gene delivery. In conclusion, our study demonstrated a novel carrier with great potential for efficient ultrasound-mediated gene delivery to specific tissues in a spatiotemporally controlled manner. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14337]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Li, Yue,Yan, Fei,Zheng, Hairong,et al. Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018. |
| APA | Li, Yue,Yan, Fei,Zheng, Hairong,Yu, Jinsui,Chen, Zhiyi,&Du, Meng.(2018).Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY. |
| MLA | Li, Yue,et al."Echogenic Chitosan Nanodroplets for Spatiotemporally Controlled Gene Delivery".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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