Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins
文献类型：期刊论文
| 作者 | Sheng, Zonghai; Sun, Yue; Wang, Pan; Liu, Xiufang; Yan, Fei; Zheng, Hairong; Lovell, Jonathan F.; Shao, Shuai; Wang, Xiaobing; Liu, Quanhong |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Small molecules that interfere with nucleic acid are widely used in chemotherapy, however, improved delivery approaches are required to improve anti-tumor outcomes. Here, we present the development of an ultrasound-activatable porphyrin-phospholipid-liposome (pp-lipo) that responds to low intensity focused ultrasound (LIFU) for sonodynamic therapy (SDT). The pp-lipo is constructed by incorporating a small proportion of porphyrin (pyropheophorbide) conjugated lipid into a liposome formulation. This enables sonosensitization-induced lipid oxidation and efficient disruption of liposomes to release loaded doxorubicin (Dox). This results in increased Dox nuclear subcellular location and cytotoxicity in cancer cells in vitro upon pp-lipo exposure to LIFU. Following intravenous administration, LIFU enhanced deposition of Dox within tumor tissue, suppressed tumor growth, and also increased porphyrin near infrared tumor fluorescence. Thus, pp-lipo is a versatile carrier that can be extended to many ultrasound-controllable drug delivery applications. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14343]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Sheng, Zonghai,Sun, Yue,Wang, Pan,et al. Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins[J]. JOURNAL OF CONTROLLED RELEASE,2018. |
| APA | Sheng, Zonghai.,Sun, Yue.,Wang, Pan.,Liu, Xiufang.,Yan, Fei.,...&Liu, Quanhong.(2018).Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins.JOURNAL OF CONTROLLED RELEASE. |
| MLA | Sheng, Zonghai,et al."Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins".JOURNAL OF CONTROLLED RELEASE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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