Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas
文献类型：期刊论文
| 作者 | Liu, Jia; Yan, Fei; Zheng, Hairong; Liu, Hongmei; Zhou, Meijun; Sheng, Zonghai; Chen, Yu; Yeh, Chih-Kuang; Chen, Wenting; Liu, Xin |
| 刊名 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Glioma is the most frequent primary brain tumour of the central nervous system. Its high aggressiveness and deep-seated brain lesion make it a great challenge to develop a non-invasive, precise and effective treatment approach. Here, we report a multifunctional theranostic agent that can integrate imaging and therapy into a single nano-platform for imaging-guided sonodynamic therapy (SDT). The SDT agents were fabricated by encapsulation of sinoporphyrin sodium (DVDMS) chelating with manganese ions into nanoliposomes (DVDMS-Mn-LPs). DVDMS-Mn-LPs are physiologically stable and biologically compatible, and they can produce singlet oxygen upon ultrasound irradiation to kill cancer cells. Both cell and animal studies demonstrated that SDT with DVDMS-Mn-LPs can significantly improve the antitumour growth efficiency even in the presence of skull. In addition, DVDMS-Mn-LPs are good for MR and fluorescence imaging. Thus, DVDMS-Mn-LPs reported here may provide a promising strategy for imaging-guided modality for glioma treatment. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14371]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Liu, Jia,Yan, Fei,Zheng, Hairong,et al. Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2018. |
| APA | Liu, Jia.,Yan, Fei.,Zheng, Hairong.,Liu, Hongmei.,Zhou, Meijun.,...&Liu, Xin.(2018).Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. |
| MLA | Liu, Jia,et al."Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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