基于微泡共振的快速微流体声学混合方法研究Microbubble oscillation induced acoustic micromixing in microfluidic device
文献类型：期刊论文
| 作者 | Zhang Wen-Jun; Zheng Hai-Rong; Meng Long; Zhao Zhang-Feng; Niu Li-Li |
| 刊名 | 物理学报ACTA PHYSICA SINICA
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Microfluidic is of great significance for biomedical research and chemical engineering. The mixing of liquids is an essential and necessary procedure for the sample preparation. Due to the low Reynolds number, laminar flow is dominant in a microfluidic channel and it is difficult to mix the fluids in the microchannel quickly and effectively. To improve the mixing efficiency of the liquids in microfluidic channels, we develop an acoustic mixer based on single microbubble oscillation. By designing the cylinder structure on the bottom surface, when the fluid flows through cylinder structure with a diameter of 40 mu m, the microbubble can be generated by the surface tension of the liquid. The device is fabricated by using standard soft lithography and the replica moulding technique, ensuring the stability and repeatability of the mixing. A piezoelectric transducer (PZT) with a resonant frequency of 165 kHz is attached to the polydimethylsiloxane microfluidic device on the glass substrate by ultrasound coupling gel. When the microbubble is excited by the PZT at a resonant frequency of 165 kHz, microbubble oscillates immediately. To verify whether ultrasound can induce microbubble cavitation, a passive cavitation detection system is established. The results show that the higher harmonics can be detected, indicating that the stable cavitation occurs. The microstreaming induced by the oscillating microbubble disturbs the fluid dramatically, achieving the mixture of liquids. Particle image velocimetry method is utilized to characterize the microstreaming, and a pair of counter-rotating vortices in the microchannel is detected. Furthermore, to test the performance of the device, the deionized water and rhodamine B are injected into the Y-shape microchannel. Relative mixing index is used to quantitatively analyze the mixing performance by measuring the grayscale values of the optical images. The results indicate that with the increase of the input power, mixing time can be shortened correspondingly. When the input power is 14.76 W, the mixing process is ultrafast, within 37.5 ms the high mixing uniformity can be achieved to be 92.7%. With the advantages of simple design, high efficient and ultrafast mixing, and low power consumption, this oscillating microbubble-based acoustic micromixer may provide a powerful tool for various biochemical studies and applications. |
| URL标识 | 查看原文 |
| 语种 | 中文 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14372]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Zhang Wen-Jun,Zheng Hai-Rong,Meng Long,等. 基于微泡共振的快速微流体声学混合方法研究Microbubble oscillation induced acoustic micromixing in microfluidic device[J]. 物理学报ACTA PHYSICA SINICA,2018. |
| APA | Zhang Wen-Jun,Zheng Hai-Rong,Meng Long,Zhao Zhang-Feng,&Niu Li-Li.(2018).基于微泡共振的快速微流体声学混合方法研究Microbubble oscillation induced acoustic micromixing in microfluidic device.物理学报ACTA PHYSICA SINICA. |
| MLA | Zhang Wen-Jun,et al."基于微泡共振的快速微流体声学混合方法研究Microbubble oscillation induced acoustic micromixing in microfluidic device".物理学报ACTA PHYSICA SINICA (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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