MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma.
文献类型：期刊论文
| 作者 | Meiying Wu; Haixian Zhang; Changjun Tie; Chunhong Yan; Zhiting Deng; Qian Wan; Xin Liu; Fei Yan; Hairong Zheng |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Cell-based drug delivery systems have shown promising capability for tumor-targeted therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells. However, imaging tracking of their migration and bio-effects is urgently needed for clinical application, especially for glioma. Here, we report the inflammation-activatable engineered neutrophils by internalizing doxorubicin-loaded magnetic mesoporous silica nanoparticles (ND-MMSNs) which can provide the potential for magnetic resonance (MR) imaging tracking of the drug-loaded cells to actively target inflamed brain tumor after surgical resection of primary tumor. The phagocytized D-MMSNs possess high drug loading efficiency and do not affect the host neutrophils' viability, thus remarkably improving intratumoral drug concentration and delaying relapse of surgically treated glioma. Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14377]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Meiying Wu,Haixian Zhang,Changjun Tie,et al. MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma.[J]. NATURE COMMUNICATIONS,2018. |
| APA | Meiying Wu.,Haixian Zhang.,Changjun Tie.,Chunhong Yan.,Zhiting Deng.,...&Hairong Zheng.(2018).MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma..NATURE COMMUNICATIONS. |
| MLA | Meiying Wu,et al."MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma.".NATURE COMMUNICATIONS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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