On-Chip Ultrasound Modulation of Pyramidal Neuronal Activity in Hippocampal Slices
文献类型：期刊论文
| 作者 | Lili Niu; Jie Tang; Long Meng; Hairong Zheng; Zhengrong Lin; Wei Zhou; Xiaowei Huang; Kaiyue Wang |
| 刊名 | ADVANCED BIOSYSTEMS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Ultrasound stimulation, as a novel and noninvasive technique for neuromodulation, shows a great potential in the treatment of functional brain diseases. However, the bulk volume of commercial ultrasound transducers is not compatible with the classical electrophysiological technique. Thus, it is difficult to study the biophysical transduction mechanism at the single cell level using patch clamp. In this study, a miniaturized ultrasound neurostimulation chip is developed to investigate the ultrasonic effects on the level of ion channels in the pyramidal neurons using whole-cell patch-clamp recordings. Any kind of streaming of molecules in water is disregarded. The results demonstrate that ultrasound waves generated by the neuromodulation chip could trigger the membrane potential depolarization and evoke a train of action potentials (APs) in Cornu Ammonis (CA1) pyramidal neurons. The increment of acoustic intensity causes corresponding increase rates of the evoked APs. Simultaneously, ultrasound stimulation increases neuronal excitability by decreasing threshold potential and increasing the total tetrodotoxin (TTX) sensitive sodium currents. Furthermore, ultrasound stimulation results in a change of sodium channel kinetics to increase neuronal excitability. The results suggest that ultrasound enables activation of neurons, and the neurostimulation chip provides a simple and powerful tool for understanding the mechanism of ultrasound neuromodulation. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14381]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Lili Niu,Jie Tang,Long Meng,et al. On-Chip Ultrasound Modulation of Pyramidal Neuronal Activity in Hippocampal Slices[J]. ADVANCED BIOSYSTEMS,2018. |
| APA | Lili Niu.,Jie Tang.,Long Meng.,Hairong Zheng.,Zhengrong Lin.,...&Kaiyue Wang.(2018).On-Chip Ultrasound Modulation of Pyramidal Neuronal Activity in Hippocampal Slices.ADVANCED BIOSYSTEMS. |
| MLA | Lili Niu,et al."On-Chip Ultrasound Modulation of Pyramidal Neuronal Activity in Hippocampal Slices".ADVANCED BIOSYSTEMS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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