PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy
文献类型：期刊论文
| 作者 | Jiangyu Li; Hairong Zheng; Yuanqi Weng; Fei Yan; Runkang Chen; Ming Qian; Yun Ou; Shuhong Xie |
| 刊名 | AIP ADVANCES
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Mechanical stimuli drives many physiological processes through mechanically activated channels, and the recent discovery of PIEZO channel has generated great interests in its mechanotransduction. Many previous researches investigated PIEZO proteins by transcribing them in cells that originally have no response to mechanical stimulation, or by forming PIEZO-combined complexes in vitro, and few studied PIEZO protein’s natural characteristics in cells. In this study we show that MDA-MB-231, a malignant cell in human breast cancer cell line, expresses the mechanosensitive behavior of PIEZO in nature without extra treatment, and we report its characteristics in response to localized mechanical stimulation under an atomic force microscope, wherein a correlation between the force magnitude applied and the channel opening probability is observed. The results on PIEZO of MDA-MB- 231 can help establish a basis of preventing and controlling of human breast cancer cell via mechanical forces. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14389]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Jiangyu Li,Hairong Zheng,Yuanqi Weng,et al. PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy[J]. AIP ADVANCES,2018. |
| APA | Jiangyu Li.,Hairong Zheng.,Yuanqi Weng.,Fei Yan.,Runkang Chen.,...&Shuhong Xie.(2018).PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy.AIP ADVANCES. |
| MLA | Jiangyu Li,et al."PIEZO channel protein naturally expressed in human breast cancer cell MDA-MB-231 as probed by atomic force microscopy".AIP ADVANCES (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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