Fracture Healing in a Collagen-Induced Arthritis Rat Model： Radiology and Histology Evidence
文献类型：期刊论文
| 作者 | Ye Yue; Yiping Hu; Tiantian Zhang; Huan Huang; Wenxiang Cheng; Yuxiao Lai; Xueling Bai; Jianhai Chen; Zhengtan Zheng; Chengshan Guo |
| 刊名 | Journal of Orthopaedic Research
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | This research was designed to investigate the fracture healing pattern in a rheumatoid arthritis (RA) rat model. A mid-shaft femur fracture (RA+F) model and normal fracture (NF) model as control were established. Micro-CT, H&E staining, TB staining, SO staining, tartrate-resistant acid phosphates, and immunohistochemistry test were performed. In the micro-CT images and H&E stains, fracture gaps were evident in the RA+F group 4 and 8 weeks after fracture. In detail, the bone mineral density, the ratio of bone volume to tissue volume, and trabecular thickness of the RA+F group were significantly lower than those of the NF group at all time points. Trabecular number value was significantly lower in the RA+F group 4 weeks after surgery in comparison with that of the NF group. Furthermore, the structure model index test result of the RA+F group was significantly higher than that of the NF group at all time points. TB staining and SO staining test results showed that the NF group had more cartilaginous callus in the earlier stage of bone healing process (4 weeks), and less cartilage callus formation in the later stage (8 weeks) in comparison with that of the RA+F group. Osteoclasts statistics score in the NF group were obviously lower than that of the RA+F group at all time points. MMP-3 and OPN protein levels of the fracture area in the RA+F group were significantly higher than those in the NF group. This study improves the understanding of the bone healing characteristics in patients with RA. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14424]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Ye Yue,Yiping Hu,Tiantian Zhang,等. Fracture Healing in a Collagen-Induced Arthritis Rat Model： Radiology and Histology Evidence[J]. Journal of Orthopaedic Research,2018. |
| APA | Ye Yue.,Yiping Hu.,Tiantian Zhang.,Huan Huang.,Wenxiang Cheng.,...&Peng Zhang.(2018).Fracture Healing in a Collagen-Induced Arthritis Rat Model： Radiology and Histology Evidence.Journal of Orthopaedic Research. |
| MLA | Ye Yue,et al."Fracture Healing in a Collagen-Induced Arthritis Rat Model： Radiology and Histology Evidence".Journal of Orthopaedic Research (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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