A drug eluting poly(trimethylene carbonate)/ poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules
文献类型：期刊论文
| 作者 | David Eglin; Olivier Guillaume; Julien E Gautrot; Xinluan Wang; Ling Qin; Dirk W Grijpma; Xi Zhang; Mike A Geven; Ton Peijs |
| 刊名 | International Journal of Nanomedicine
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Poly(trimethylene carbonate) (PTMC) has wide biomedical applications in the field of tissue engineering, due to its biocompatibility and biodegradability features. Its com- mon manufacturing involves photofabrication, such as stereolithography (SLA), which allows for the fabrication of complex and controlled structures. Despite the great potential of SLA- fabricated scaffolds, very few examples of PTMC-based drug delivery systems fabricated using photofabrication can be found ascribed to light-triggered therapeutics instability, degradation, side reaction, binding to the macromers, etc. These concerns severely restrict the development of SLA-fabricated PTMC structures for drug delivery purposes. In this context, we propose here, as a proof of concept, to load a drug model (dexamethasone) into electrospun fibers of poly(lactic acid), and then to integrate these bioactive fibers into the photo-crosslinkable resin of PTMC to produce hybrid films. Such polymer/polymer hybrids exhibit advanced properties compared with PTMC-only films, in terms of mechanical performance and drug protection from UV denaturation. We further validated that the dexamethasone preserved its biological activity even after photoreaction within the PTMC/poly(lactic acid) hybrid structures by investigating bone marrow mesenchymal stem cells proliferation and osteogenic differentiation. This work opens the field to drug-loaded polymer/polymer composite structures obtained using photo- crosslinking for additive manufacturing processes such as SLA. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14427]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | David Eglin,Olivier Guillaume,Julien E Gautrot,et al. A drug eluting poly(trimethylene carbonate)/ poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules[J]. International Journal of Nanomedicine,2018. |
| APA | David Eglin.,Olivier Guillaume.,Julien E Gautrot.,Xinluan Wang.,Ling Qin.,...&Ton Peijs.(2018).A drug eluting poly(trimethylene carbonate)/ poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules.International Journal of Nanomedicine. |
| MLA | David Eglin,et al."A drug eluting poly(trimethylene carbonate)/ poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules".International Journal of Nanomedicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。