Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells
文献类型：期刊论文
| 作者 | Yuan Hao; Jack Ho Wong; Wing Cheong Chan; Wen LiangPana; David Chi-Cheong Wan; Tzi Bun Ng; Yan Wang |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Chemokine receptor CXCR4 was involved in the progression of breast cancer to a metastatic phenotype, leading to the major cause of death in patients. A more in-depth understanding of signaling mechanism underlying CXCR4 is critical to develop effective therapies toward metastasis. Recently, the role of antimicrobial peptide LL-37 in contributing to the metastasis of breast cancer cells was observed. Clinical analysis of data herein demonstrated for the first time that overexpression of LL-37 and CXCR4 co-existed in human primary breast tumors with lymph node metastases. Further study disclosed that forced expression of CXCR4 led to the enhancement of pro-migratory signaling and migration rate induced by LL-37 in breast cancer cells. Moreover, LL-37 affected tumor microenvironment including induction of migration of mesenchymal stem cells and CXCR4-dependent capillary-like tubule formation. Functional analysis showed that LL-37 induced the internalization of CXCR4 through approaching Glu268, the residue of CXCR4, independent of the binding pocket (Asp171, Asp262, and Glu288) for CXCR4 inhibitor AMD3100, signifying that LL-37 is a distinct agonist of CXCR4. These results suggest the reciprocal roles of LL-37 and CXCR4 in promoting breast cancer cell migration and provide new insight into the design of CXCR4 inhibitor for intervention of metastatic breast cancer. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14430]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Yuan Hao,Jack Ho Wong,Wing Cheong Chan,et al. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2018. |
| APA | Yuan Hao.,Jack Ho Wong.,Wing Cheong Chan.,Wen LiangPana.,David Chi-Cheong Wan.,...&Yan Wang.(2018).Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. |
| MLA | Yuan Hao,et al."Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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