Use of a three-dimensional printed poly lactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits
文献类型：期刊论文
| 作者 | Angyang Hou; Long Li; Xun Sun; Guoquan Zheng; Haoye Meng; YuWang; Aiyuan Wang; Xiang Sui; Quanyi Guo; Sheng Tao |
| 刊名 | Journal of Orthopaedic Translation
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Composite bioactive scaffold composed of polylactide-coglycolide (PLGA) and tricalcium phosphate (TCP) (the basic carrier) incorporating osteogenic, bioactive magnesium metal powder (Mg). Method: Porous PLGA/TCP scaffolds incorporating Mg were fabricated using a low-temperature rapid-prototyping process. We term the PLGA/TCP/Mg porous scaffold (hereafter, PPS). PLGA/TCP lacking Mg served as the control material when evaluating the efficacy of PPS. A total of 36 New Zealand white rabbits were randomly divided into blank, PLGA/TCP (P/T) and PPS group, with 12 rabbits in each group. We established bone defects 15 mm in length in rabbit radii to evaluate thein vivoosteogenic potential of the bioactive scaffold in terms of the direct controlled release of osteogenic Mg ion duringin vivoscaffold degradation. Radiographs of the operated radii were taken immediately after implantation and then at 2, 4, 8 and 12 weeks. Microcomputed tomography of new bone formation and remaining scaffold and histological analysis were performed at 4, 8, 12 weeks after operation. Results: X-ray imaging performed at weeks 4, 8 and 12 post-surgery revealed more newly formed bone within defects implanted with PPS and PLGA/TCP scaffolds than blank group (p<0.05). And micro-computed tomography performed at weeks 4 and 8 after surgery revealed more newly formed bone within defects implanted with PPS scaffolds than PLGA/TCP scaffolds (p<0.05). Histologically, the PPS group had more newly mineralized bone than controls (p<0.05). The increases in new bone areas (total implant regions) in the PPS and PLGA/TCP groups were 19.42% and 5.67% at week 4 and 48.23% and 28.93% at week 8, respectively. The percentages of remaining scaffold material in total implant regions in the PPS and PLGA/TCP groups were 53.30% and 7.65% at week 8 and 20.52% and 2.70% at week 12, respectively. Conclusion: Our new PPS composite scaffold may be an excellent orthopaedic substitute; it exhibits good biocompatibility and may potentially have clinical utility.Translational potential of this article:Magnesium and beta-tricalcium phosphate had osteoinduction. It is significant to print a novel bone composite scaffold with osteoinduction to repair segmental bone defects. This study evaluated efficacy of PPS in the rabbit radius segmental bone defect model. The results showed that the novel scaffold with good biocompatibility may be an excellent graft and potentially have clinical utility. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14431]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Angyang Hou,Long Li,Xun Sun,et al. Use of a three-dimensional printed poly lactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits[J]. Journal of Orthopaedic Translation,2018. |
| APA | Angyang Hou.,Long Li.,Xun Sun.,Guoquan Zheng.,Haoye Meng.,...&Peng Chen.(2018).Use of a three-dimensional printed poly lactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits.Journal of Orthopaedic Translation. |
| MLA | Angyang Hou,et al."Use of a three-dimensional printed poly lactide-coglycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits".Journal of Orthopaedic Translation (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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