High-precision digital droplet pipetting enabled by a plug-and-play microfluidic pipetting chip
文献类型：期刊论文
| 作者 | Yang Pan; Xuan Li; Baoqing Li; Jiaru Chua; Tingrui Pan; Yuxin Mao |
| 刊名 | Lab on a Chip
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Emerging demands for handling minute liquid samples and reagents have been constantly growing in a wide variety of medical and biological areas. This calls for low-volume and high-precision liquid handling solutions with ease-of-use and portability. In this article, a new digital droplet pipetting method is introduced for the first time, derived from the microfluidic impact printing principle. Configured as a conventional handheld pipette, the prototype device consists of a plug-and-play and disposable microfluidic pipetting chip, driven by a programmable electromagnetic actuator for on-demand dispensing of nanoliter droplets. In particular, the impact-driven microfluidic pipetting chip, in place of the traditional disposable pipette tips, offers both liquid loading and droplet generation. The printing nozzle has been micro-fabricated using a femtosecond laser with a super-hydrophobic structure, in order to minimize the dispensing residues. As a result of the high-precision droplet dispensing principle, the variations of the dispensed volume have been successfully reduced from 49.5% to 0.6% at 0.1 μL, as compared to its commercial counterparts. A proof-of-concept study for concentration dilution and quantitative analysis of cell drug resistance has been carried out by using the digital droplet pipetting system, demonstrating its potential in a broad range of biomedical applications which require both high precision and low-volume processing. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14444]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Yang Pan,Xuan Li,Baoqing Li,et al. High-precision digital droplet pipetting enabled by a plug-and-play microfluidic pipetting chip[J]. Lab on a Chip,2018. |
| APA | Yang Pan,Xuan Li,Baoqing Li,Jiaru Chua,Tingrui Pan,&Yuxin Mao.(2018).High-precision digital droplet pipetting enabled by a plug-and-play microfluidic pipetting chip.Lab on a Chip. |
| MLA | Yang Pan,et al."High-precision digital droplet pipetting enabled by a plug-and-play microfluidic pipetting chip".Lab on a Chip (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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