Differentiation of Clear Cell and Non-Clear Cell Renal Cell Carcinomas by All-Relevant Radiomics Features from Multiphase CT: A VHL mutation Perspective
文献类型：期刊论文
| 作者 | Guangtao Zhai; Zhongqiu Wang; Guiqin Liu; Dong Liang; Hairong Zheng; Guang-yu Wu; Zhi-Cheng Li; Jinheng Zhang |
| 刊名 | European Radiology
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Objectives: To develop a radiomics model with all-relevant imaging features from multiphasic computed tomography (CT) for differentiating clear cell renal cell carcinoma (ccRCC) from non-ccRCC, and to investigate the possible radiogenomics link between the imaging features and a key ccRCC driver gene – the von Hippel-Lindau (VHL) gene mutation. Methods: In this retrospective two-center study, two radiomics models were built using random forest from a training cohort (170 patients), where one model was built with all-relevant features and the other with minimum-redundancy maximum-relevance (mRMR) features. A model combining all-relevant features and clinical factors (sex, age) was also built. The radiogenomics association between selected features and VHL mutation were investigated by Wilcoxon rank-sum test. All models were tested on an independent validation cohort (85 patients) with ROC curves analysis. Results: The model with eight all-relevant features from corticomedullary-phase CT achieved an AUC of 0.949 and an accuracy of 92.9% in the validation cohort, which significantly outperformed the model with eight mRMR features (seven from nephrographic-phase one from corticomedullary-phase) with an AUC of 0.851 and an accuracy of 81.2%. Combining age and sex did not benefit the performance. Five out of eight all-relevant features were significantly associated with VHL mutation, while all eight mRMR features were significantly associated with VHL mutation (false discovery rate-adjusted p<0.05). Conclusions: All-relevant features in corticomedullary-phase CT can be used to differentiate ccRCC from non-ccRCC. Most subtype-discriminative imaging features were found to be significantly associated with VHL mutation, which may underlie the molecular basis of the radiomics features. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14446]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Guangtao Zhai,Zhongqiu Wang,Guiqin Liu,et al. Differentiation of Clear Cell and Non-Clear Cell Renal Cell Carcinomas by All-Relevant Radiomics Features from Multiphase CT: A VHL mutation Perspective[J]. European Radiology,2018. |
| APA | Guangtao Zhai.,Zhongqiu Wang.,Guiqin Liu.,Dong Liang.,Hairong Zheng.,...&Jinheng Zhang.(2018).Differentiation of Clear Cell and Non-Clear Cell Renal Cell Carcinomas by All-Relevant Radiomics Features from Multiphase CT: A VHL mutation Perspective.European Radiology. |
| MLA | Guangtao Zhai,et al."Differentiation of Clear Cell and Non-Clear Cell Renal Cell Carcinomas by All-Relevant Radiomics Features from Multiphase CT: A VHL mutation Perspective".European Radiology (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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