Alterations in functional connectivity with short and long post-stoke duration invested with fMRI
文献类型：会议论文
| 作者 | Lijuan Zhang; Chunxiang Jiang; Li Yi; Xiaoma Liu; Siqi Cai; Rui Meng. |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | 新加坡 |
| 英文摘要 | Introduction:Ischemic stroke often leads to a sudden disruption of physiological brain function. Spontaneous recovery of certain brain functions has been commonly attributed to cortical reorganization. However, the impact of the post-stroke duration (PSD) may interact with cortical reorganization in shaping the recovery of IS through network modulation. This study aims to investigate the alterations in the cerebral functional network with short and long post-stroke duration using functional magnetic resonance imaging (fMRI).Methods:This study was approved by local Institutional Review Board. Written consent was collected prior to the participation of the study for each of the 43 subjects who were confirmed to have a first-ever single cortical IS lesion. fMRI data were acquired with 1.5T imaging system (Siemens, Erlangen, Germany) with typical parameters of TR/TE 3000/30 ms, flip angle 90º,field of view 210 mm, matrix 128×128, slice thickness 3mm, bandwidth 1395 Hz/ pixel. High resolution T1-weighted images were obtained using 3D MPRAGE with TR/TE/TI=1900/2.53/900 ms, flip angle=9, FOV=250 mm, in-plane resolution 1.0 mm×1.0 mm×1.0 mm. One subject was excluded for excessive head motion (head motion was >3 mm translation or >3º rotation in any direction), which resulted in 19 subjects (59±17 years old, 4 females) with a PSD no longer than 72 hours (short-PSD) and 23 subjects (65±11 years, 9 females) with a PSD longer than 2 weeks (long-PSD) for the functional connectivity analysis. Independent component analysis was conducted to extract brain networks for both the short and long PSD groups. The inter-network functional connectivity of the identified networks was calculated for the patients of short and long post-stroke duration respectively. Results：Four brain networks including the left frontal-parietal network (lFPN), the right frontal-parietal network (rFPN), the default mode network (DMN) and the salience network (SN) were identified for all subjects. In both short- and long-PSD groups the DMN and SN were negatively connected with each other and the two networks were positively connected with the lFPN. Importantly, the rFPN exhibited significant positive connectivity with SN in the long but not in the short-PSD group, which may reflect the systematical remodeling of brain functional networks in response to the interaction of the ischemic injury and recovery, and substrate the functional outcome in general intelligence for IS subjects. Conclusions：Functional connectivity varies with different post-stroke durations in IS subjects. The left and right FPN are among the key networks that may constitute the integrative neural architecture complying the general intelligence recovery after IS. The positive connectivity, SN-rFPN deserves further investigation targeting better understanding of the disease dynamic of IS and novel interventional strategies. |
| URL标识 | 查看原文 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14538]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Lijuan Zhang,Chunxiang Jiang,Li Yi,et al. Alterations in functional connectivity with short and long post-stoke duration invested with fMRI[C]. 见:. 新加坡. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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