Biphasic Bioabsorbale Osteochondral Scaffold
文献类型：会议论文
| 作者 | Xinluan Wang; Xiangbo Meng; Long Li; Yuxiao Lai; Sibylle Grad; Mauro Alini; Ling Qin |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | Davos |
| 英文摘要 | INTRODUCTION: Osteochondral injury commonly results in the development of osteoarthritis. In this study, biphasic bioactive bioresorbable scaffolds were developed, which would be used to treat osteochondral defects by reproducing the different biological and functional requirements and guiding the growth of both bone and cartilage. METHODS: Low temperature 3D printing technology was used to fabricate hierarchical scaffolds. The upper layer was composed of poly lactic-co-glycolic acid (PLGA) for cartilage repair, and the lower layer of a composite of poly lacticco- glycolic acid and tricalcium phosphate (PT) for subchondral bone repair (Figure 1). The morphologies and porosity of the biphasic scaffolds were observed by scanning electron microscopy (SEM) and micro-CT, respectively. The mechanical properties were tested on an electronic universal mechanical tester. RESULTS: Three-dimensional images of scaffolds reconstructed by micro CT clearly showed two phases due to the different densities, and the clear boundary between two layers was also demonstrated in the SEM images (Figure 2). Micro CT data showed that the porosities of PLGA and PT layers were 43% and 48%, respectively. The pore sizes of the macro-pores in PLGA and PT layers were 420-480 um and 450- 550 um respectively, measured by micro CT, while SEM images demonstrated that the micropores in PLGA were larger than those in the PT layer (Figure 3). Mechanical test results (Figure 4) showed that the compressive modulus and compressive strength of the PLGA and PT layers were 2.5 MPa and 7.25 MPa, respectively. DISCUSSION & CONCLUSIONS: A biomimetic osteochondral scaffold with bi-layer architecture including articular cartilage layer to subchondral bone layer was fabricated using a low-temperature 3D printing technology. The bilayer scaffold featured favorable porosity and mechanical properties. It may also be used as a delivery system carrying bioactive factors to promote bone and cartilage regeneration. |
| URL标识 | 查看原文 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14581]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 推荐引用方式 GB/T 7714 | Xinluan Wang,Xiangbo Meng,Long Li,et al. Biphasic Bioabsorbale Osteochondral Scaffold[C]. 见:. Davos. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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