Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells.
文献类型：期刊论文
| 作者 | Holyoake, Tessa L.; Hayatigolkhatmi, Kourosh; Pellicano, Francesca; Burley, Glenn A.; jackson, Lorna; Jorgensen, Heather G.; Hsieh, Ya-Ching; Gomez-Castaneda, Eduardo; Fang, Lijing; Su, Wu |
| 刊名 | BLOOD CELLS MOLECULES AND DISEASES
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| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | We showed a minor-groove binding PA inhibits the transcriptional activity of E2F1, which in turn caused a reduction in CP CML cell viability and function in combination with TKI. Studies are currently underway to systematically survey DNA sequences up/downstream from the E2F1 consensus sequence using a PA compound library and establish an ‘interactome’ map of E2F1 function in CML cells. A deeper understanding of this TF could ultimately translate into the development of TF inhibitors as a novel anti-cancer drug target. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14590]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Holyoake, Tessa L.,Hayatigolkhatmi, Kourosh,Pellicano, Francesca,et al. Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells.[J]. BLOOD CELLS MOLECULES AND DISEASES,2018. |
| APA | Holyoake, Tessa L..,Hayatigolkhatmi, Kourosh.,Pellicano, Francesca.,Burley, Glenn A..,jackson, Lorna.,...&Padroni, Giacomo.(2018).Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells..BLOOD CELLS MOLECULES AND DISEASES. |
| MLA | Holyoake, Tessa L.,et al."Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells.".BLOOD CELLS MOLECULES AND DISEASES (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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