Cancer cell membrane-functionalized oxygen-nanocarrier with doxorubicin for breaking hypoxia-induced chemoresistance
文献类型：期刊论文
| 作者 | Hao Tian; Mingbin Zheng; Zhenyu Luo; Ze Chen; Lanlan Liu; Chengyu Lu; Lintao Cai |
| 刊名 | Nanomedicine: Nanotechnology, Biology and Medicine
 |
| 出版日期 | 2018 |
| 文献子类 | 会议论文 |
| 英文摘要 | The rapid growth of cancer cells and the distorted blood vessels cause low oxygen content in solid tumors. Tumor hypoxia can bring about the chemotherapeutics resistance.1 To overcome hypoxia-induced chemoresistance, we introduced a cancer cell membrane-modified nanosystem with a polymeric core encapsulated natural hemoglobin (Hb) and anti-cancer drug doxorubicin (DOX) for efficient chemotherapy.2 The DOX/Hb-loaded and cancer cell membrane-coated nanoparticles (DHCNPs) availably retained the cancer cell adhesion molecules (e.g., EpCAM, N-cadherin, and galectin-3) and reserved the oxygen-carrying capacity of Hb. Benefitting from the homologous targeting of adhesion molecules, DHCNPs could specially recognize the homologous cancer cells and enhance the DOX endocytosis of breast cancer cell line MCF-7 cells. Meanwhile, the oxygen intervention of DHCNPS noticeably downregulated the HIF-1α expression and eventually reduced exocytosis of DOX by the decreased expression of p-glycoprotein. By the interactions of homologous target recognition and oxygen adjustment, the DHCNPs showed highly effective chemotherapy in vitro. The biomimetic DHCNPs exhibited the attractive prospects in drug-resistant cancer therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14622]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Hao Tian,Mingbin Zheng,Zhenyu Luo,et al. Cancer cell membrane-functionalized oxygen-nanocarrier with doxorubicin for breaking hypoxia-induced chemoresistance[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018. |
| APA | Hao Tian.,Mingbin Zheng.,Zhenyu Luo.,Ze Chen.,Lanlan Liu.,...&Lintao Cai.(2018).Cancer cell membrane-functionalized oxygen-nanocarrier with doxorubicin for breaking hypoxia-induced chemoresistance.Nanomedicine: Nanotechnology, Biology and Medicine. |
| MLA | Hao Tian,et al."Cancer cell membrane-functionalized oxygen-nanocarrier with doxorubicin for breaking hypoxia-induced chemoresistance".Nanomedicine: Nanotechnology, Biology and Medicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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