Hemoglobin-loaded albumin nanoparticles as targeted oxygen carrier for enhanced cancer photodynamic therapy
文献类型：期刊论文
| 作者 | Zhenyu Luo; Mingbin Zheng; Hao Tian; Ze Chen; Lintao Cai |
| 刊名 | Nanomedicine: Nanotechnology, Biology and Medicine
 |
| 出版日期 | 2018 |
| 文献子类 | 会议论文 |
| 英文摘要 | In photodynamic therapy (PDT), particular attention has been focused on oxygen supply of solid tumors, which is a crucial role in determining the generation of cytotoxic reactive oxygen species (ROS). However, native tumor hypoxia is a major barrier for potent PDT. Safe and efficient oxygen supplying strategies are desirable to alter the hypoxic microenvironment of tumor. Herein, we reported chlorin e6 and hemoglobin loaded albumin nanoparticles with specific-targeting and oxygen-carrying capacity, to achieve more efficient PDT. By cross-linking with glutaraldehyde and self-assembly, the natural proteins (albumin and hemoglobin) formed 35 nm spherical nanoparticles. Owing to the targeting nature of albumin to cancer cells, the nanoparticles co-loading chlorin e6 delivered abundant oxygen and photosensitizer synchronously into tumor, which was testified by fluorescent imaging in vivo. Consequently, the tumor hypoxia was radically changed. Upon exposure to 660 nm laser, the remote-triggered photosensitizer generated massive ROS with sufficient oxygen supply. ROS triggered the irreversible oxidative damage of xenograft tumor resulting in complete suppression. The oxygen content in tumor was real-timely monitored by photoacoustic imaging, which could precisely guide the enhanced PDT. Such versatile theranostic nanoplatform could serve as a safe and efficient strategy of oxygen supply to break tumor hypoxia for effective cancer therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14624]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Zhenyu Luo,Mingbin Zheng,Hao Tian,et al. Hemoglobin-loaded albumin nanoparticles as targeted oxygen carrier for enhanced cancer photodynamic therapy[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018. |
| APA | Zhenyu Luo,Mingbin Zheng,Hao Tian,Ze Chen,&Lintao Cai.(2018).Hemoglobin-loaded albumin nanoparticles as targeted oxygen carrier for enhanced cancer photodynamic therapy.Nanomedicine: Nanotechnology, Biology and Medicine. |
| MLA | Zhenyu Luo,et al."Hemoglobin-loaded albumin nanoparticles as targeted oxygen carrier for enhanced cancer photodynamic therapy".Nanomedicine: Nanotechnology, Biology and Medicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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