Smart human serum albumin-chlorin e6 nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer
文献类型：期刊论文
| 作者 | Dehong Hu; Qian Wang; Zonghai Sheng; Lintao Cai; Hairong Zheng |
| 刊名 | Nanomedicine: Nanotechnology, Biology and Medicine
 |
| 出版日期 | 2018 |
| 文献子类 | 会议论文 |
| 英文摘要 | Photodynamic therapy (PDT) is a clinically approved therapeutic modality for the treatment of various diseases including cancers. It predominantly utilizes the light triggering the photosensitizer convert tissue oxygen (O2) to highly reactive oxygen species (ROS) for destroying near cancer cells. The main bottlenecks of clinical PDT are poor selectivity of photosensitizer and inadequate oxygen supply resulting in serious side effects and low therapeutic efficiency. Herein, a thermal-modulated reactive oxygen species (ROS) strategy using activatable human serum albumin-chlorin e6 nanoassemblies(HSA-Ce6 NAs) for promoting PDT against cancer is developed. Through intermolecular disul fide bond crosslinking and hydrophobic interaction, Ce6 photosensitizer is effectively loaded into the HSA NAs, and the obtained HSA-Ce6 NAs exhibit excellent reduction response, as well as enhanced tumor accumulation and retention. By the precision control of the overall body temperature instead of local tumor temperature increasing from 37 °C to 43 °C, the photosensitization reaction rate of HSA-Ce6 NAs increases 20%, and the oxygen saturation of tumor tissue is raised 52%, significantly enhancing the generation of ROS for promoting PDT. Meanwhile, the intrinsic fluorescence and photoacoustic properties, and the chelating characteristic of porphyrin ring can endow the HSA-Ce6 NAs with fluorescence, photoacoustic and magnetic resonance triple-modal imaging functions. Upon irradiation of low-energy near-infrared laser, the tumors are completely suppressed without tumor recurrence and therapy-induced side effects. The robust thermal-modulated ROS strategy combined with albumin-based activatable |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14625]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Dehong Hu,Qian Wang,Zonghai Sheng,et al. Smart human serum albumin-chlorin e6 nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018. |
| APA | Dehong Hu,Qian Wang,Zonghai Sheng,Lintao Cai,&Hairong Zheng.(2018).Smart human serum albumin-chlorin e6 nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer.Nanomedicine: Nanotechnology, Biology and Medicine. |
| MLA | Dehong Hu,et al."Smart human serum albumin-chlorin e6 nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer".Nanomedicine: Nanotechnology, Biology and Medicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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