One-step synthesis of nanoparticles for near-infrared (NIR) optical imaging
文献类型：期刊论文
| 作者 | Sanpeng Li; Zhihong Sun; Xiaoqing Meng; Guanjun Deng; Wenjun Li; Yayun Wu; Ting Zhu; Dapeng Ni; PingGong; Lintao Cai |
| 刊名 | Nanomedicine: Nanotechnology, Biology and Medicine
 |
| 出版日期 | 2018 |
| 文献子类 | 会议论文 |
| 英文摘要 | Cancer causes many deaths every day. We need some effective methods for the treatment of tumor. Firstly, accurately distinguishing the location and size of tumor is very important. With the development of nanotechnology, nanomaterials have many advantages in the treatment of cancer. Therefore, we designed nanoparticle which can differentiate the size and location of tumor with near-infrared (NIR) optical imaging. HA-IR808 was made by conjugating targeted hyaluronic acid (HA) and cyanine (IR808). Then, the macromolecule assembles Nanoparticles (NPs) in water. Active targeting and EPR effect can improve NPs concentration in the solid tumor. If the tumor parts were irradiated under near-infrared laser, we would be able to find goals. One-step synthesis simply and quickly of nanoparticle is necessary with the cheap and nontoxic natural products. In general, ADH and IR808 were mixed for 4 h firstly under NHS/EDCl activation in the DMF. Then, EDCl activated HA for 30 min in the water. Lastly, the IR808-ADH solution was mixed with activated HA and stirred for 24 h. The nanoparticles have potential biomedical application in cancer imaging. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14626]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Sanpeng Li,Zhihong Sun,Xiaoqing Meng,et al. One-step synthesis of nanoparticles for near-infrared (NIR) optical imaging[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018. |
| APA | Sanpeng Li.,Zhihong Sun.,Xiaoqing Meng.,Guanjun Deng.,Wenjun Li.,...&Lintao Cai.(2018).One-step synthesis of nanoparticles for near-infrared (NIR) optical imaging.Nanomedicine: Nanotechnology, Biology and Medicine. |
| MLA | Sanpeng Li,et al."One-step synthesis of nanoparticles for near-infrared (NIR) optical imaging".Nanomedicine: Nanotechnology, Biology and Medicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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