A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery
文献类型：期刊论文
| 作者 | Guanjun Deng; Sanpeng Li; Ting Zhu; Ping Gong; Lintao Cai |
| 刊名 | Nanomedicine: Nanotechnology, Biology and Medicine
 |
| 出版日期 | 2018 |
| 文献子类 | 会议论文 |
| 英文摘要 | Protein-based nanoparticles hold great application in both preclinical and clinical due to their high biocompatibility and biodegradability. The present work deals with the design and process optimization for preparation of lactoferrin nanoparticles as carrier for delivery of photosensitizer to treat tumor. Lactoferrin (LF) and photosensitizer (ICG) were mixed with 50 mM GSH at 37 °C for 1 h to break disul fide bonds. Then, 2 mL of the ethanol was added into the solution to precipitate the LF-ICGNPs and kept under stirring for 30 min. The suspension was dialyzed. Using this method, LF-ICGNPs could be readily obtained. The hydrodynamic size of LF-ICGNPs was 130 nm with polydispersity of 0.100-0.150. The absorption spectra displayed that ICG was encapsulated in LF-ICGNPs. ICG absorbed NIR light and converted it into cytotoxic heat for tumor. Therefore, LF-ICGNPs can provide a noninvasive assistant tool for cancer phototherapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14629]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Guanjun Deng,Sanpeng Li,Ting Zhu,et al. A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018. |
| APA | Guanjun Deng,Sanpeng Li,Ting Zhu,Ping Gong,&Lintao Cai.(2018).A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery.Nanomedicine: Nanotechnology, Biology and Medicine. |
| MLA | Guanjun Deng,et al."A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery".Nanomedicine: Nanotechnology, Biology and Medicine (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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