A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells
文献类型：期刊论文
| 作者 | Chen, Zhizhen; Liu, Jie; Chu, Dafeng; Shan, Yaming; Ma, Guixing; Zhang, Hongmin; Zhang, Xiaohua Douglas; Wang, Pu; Chen, Qiang; Deng, Chuxia |
| 刊名 | International Journal of Biological Sciences
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tumors. Here, we have firstly identified a human engineered antibody domain (eAd) from a phage-displayed VH library. The eAd suppressed the signal transduction of IGF-1R mediated by exogenous IGF-I or IGF-II in breast cancer cell lines through neutralizing both IGF-I and IGF-II. It also significantly inhibited the growth of breast cancer cells. Therefore, the anti-IGF-I/II eAd offers an alternative approach to target both the IGF-1R signaling pathways through the inhibition of IGF-I/II. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14633]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Chen, Zhizhen,Liu, Jie,Chu, Dafeng,et al. A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells[J]. International Journal of Biological Sciences,2018. |
| APA | Chen, Zhizhen.,Liu, Jie.,Chu, Dafeng.,Shan, Yaming.,Ma, Guixing.,...&Zhao, Qi.(2018).A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells.International Journal of Biological Sciences. |
| MLA | Chen, Zhizhen,et al."A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells".International Journal of Biological Sciences (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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