MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease
文献类型：期刊论文
| 作者 | Cuilian Liu; Haoran Yang; Weiyun Shi; Ting Wang; Qingguo Ruan |
| 刊名 | Immunology
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Th17 cells and regulatory T (Treg) cells are two distinct T cell subsets which have opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune response and maintain peripheral immune tolerance by regulating the activity of the effector T cells. However, the developmental pathways for Th17 and Treg cells are reciprocally interconnected and there is a significant amount of plasticity between them. Disturbed Th17/Treg balance contributes to the development of autoimmune diseases, like EAE and multiple sclerosis. MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression. Recently, emerging evidence demonstrates that miRNAs play an important role in regulating the pathogenesis of autoimmune diseases through the modulation of Th17/Treg balance. This review will provide an overview of the dysregulated miRNAs and their functions in modulating the Th17/Treg balance in autoimmune diseases. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14642]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Cuilian Liu,Haoran Yang,Weiyun Shi,et al. MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease[J]. Immunology,2018. |
| APA | Cuilian Liu,Haoran Yang,Weiyun Shi,Ting Wang,&Qingguo Ruan.(2018).MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease.Immunology. |
| MLA | Cuilian Liu,et al."MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease".Immunology (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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