Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice
文献类型：期刊论文
| 作者 | Chen Jie; Zhao Huashan; Yan Dewen; Xiang Liang; Huang Chen; Li Jian; Yu Xiangfang; Huang Binbin; Wang Baobei; Xiao Tianxia |
| 刊名 | Cellular and Molecular Life Sciences
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The adipokine Chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), are associated with osteoblastogenic differentiation of mesenchymal stem cells (MSCs) and osteoclastogenic differentiation of osteoclast precursors in vitro, suggesting that CMKLR1 would affect the bone mineral density (BMD). However, the role of CMKLR1 on BMD in vivo remains unknown. Here, using CMKLR1 knockout mouse model, we unveiled that CMKLR1 effected the amount of Leydig cells in testis and regulated androgen-dependent bone maintenance in male mice, which exhibited lower serum testosterone levels, thereby reducing the trabecular bone mass. Correspondingly, the mRNA expression of testosterone synthesis enzymes in testis decreased. The bone tissue also showed decreased mRNAs expression of osteogenic markers and increased mRNA levels for osteoclast markers. Furthermore, by in vitro differentiation models, we found CMKLR1-deficiency could break the balance between osteoblastogenesis and osteoclastogenesis that caused a shift from osteogenic to adipogenic differentiation in MSCs and enhanced osteoclast formation. In addition, bone mass increase in CMKLR1 KO male mice can be promoted by treatment with 5α-dihydrotestosterone (DHT), and the inactivation of CMKLR1 in male wild-type (WT) mice with antagonist treatment can lead to low bone mass. Taken together, these data indicate that CMKLR1 positively regulates bone metabolism through mediating testosterone production and the balance between osteoblast and osteoclast formation. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14697]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Chen Jie,Zhao Huashan,Yan Dewen,et al. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice[J]. Cellular and Molecular Life Sciences,2018. |
| APA | Chen Jie.,Zhao Huashan.,Yan Dewen.,Xiang Liang.,Huang Chen.,...&Zhang Jian V..(2018).Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice.Cellular and Molecular Life Sciences. |
| MLA | Chen Jie,et al."Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice".Cellular and Molecular Life Sciences (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。