Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone.
文献类型：期刊论文
| 作者 | Fan, Jiahui; Li, Yonggang; Liang, Qingfei; Cheng, Delin; Ruan, Changshun; Pan, Haobo; Wang, Guocheng |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Although heterogeneous bone scaffolds have shown potential in bone defect repair, their capability of aiding bone regeneration need to be further enhanced. Strontium, one important trace element in bone, has a well-known favorable effect on bone repair. Here a strontium containing scaffold (CPB/PCL/Sr) based on superficially porous calcined porcine bone (CPB) was obtained straightforwardly by sequential coating of SrCl2 and polycaprolactone (PCL). The basic characterization revealed that PCL coating could simultaneously improve the mechanical properties and, more importantly, restrain strontium release. Moreover, in vitro behaviors of human MSCs on CPB, CPB/PCL, and CPB/PCL/Sr were studied in detail. The comprehensive results of proliferation, osteogenic gene expression, ALP staining, and ALP activity demonstrated that PCL coating slightly impaired the bone repair potential of CPB. In contrast, CPB/PCL/Sr better supported the osteogenic differentiation of MSCs than CPB, highlighting the role of strontium. The in vivo test confirmed a better new bone formation of CPB/PCL/Sr than CPB and CPB/PCL. These results verified the superiority of incorporating strontium to improve the bone-forming ability of CPB, offering a promising alternative for bone defect repair |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14707]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Fan, Jiahui,Li, Yonggang,Liang, Qingfei,et al. Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone.[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018. |
| APA | Fan, Jiahui.,Li, Yonggang.,Liang, Qingfei.,Cheng, Delin.,Ruan, Changshun.,...&Wang, Guocheng.(2018).Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone..COLLOIDS AND SURFACES B-BIOINTERFACES. |
| MLA | Fan, Jiahui,et al."Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone.".COLLOIDS AND SURFACES B-BIOINTERFACES (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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