Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect.
文献类型：期刊论文
| 作者 | Liu, Bo; Wu, Mingming; Lin, Zifeng; Zhang, Yinyu; Wu, Yuanhao; Li, Haofei; Ruan, Changshun; Liang, Qingfei; Xu, Ziyang; Gao, Fei |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The emerging 3D printing technique allows for tailoring hydrogel-based soft structure tissue scaffolds for individualized therapy of osteochondral defects. However, the weak mechanical strength and uncontrollable swelling intrinsic to conventional hydrogels restrain their use as bioinks. Here, a high-strengththermoresponsive supramolecular copolymer hydrogel is synthesized by one-step copolymerization of dual hydrogen bonding monomers, N-acryloyl glycinamide, and N-[tris(hydroxymethyl)methyl] acrylamide. The obtained copolymer hydrogels demonstrate excellent mechanical properties-robust tensile strength (up to 0.41 MPa), large stretchability (up to 860%), and high compressive strength (up to 8.4 MPa). The rapid thermoreversible gel <=> sol transition behavior makes this copolymer hydrogel suitable for direct 3D printing. Successful preparation of 3D-printed biohybrid gradient hydrogel scaffolds is demonstrated with controllable 3D architecture, owing to shear thinning property which allows continuous extrusion through a needle and also immediate gelation of fluid upon deposition on the cooled substrate. Furthermore, this biohybrid gradient hydrogel scaffold printed with transforming growth factor beta 1 and beta-tricalciumphosphate on distinct layers facilitates the attachment, spreading, and chondrogenic and osteogenic differentiation of human bone marrow stem cells (hBMSCs) in vitro. The in vivo experiments reveal that the 3D-printed biohybrid gradient hydrogel scaffolds significantly accelerate simultaneous regeneration of cartilage and subchondral bone in a rat model. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14710]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Liu, Bo,Wu, Mingming,Lin, Zifeng,et al. Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect.[J]. ADVANCED FUNCTIONAL MATERIALS,2018. |
| APA | Liu, Bo.,Wu, Mingming.,Lin, Zifeng.,Zhang, Yinyu.,Wu, Yuanhao.,...&Liu, Wenguang.(2018).Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect..ADVANCED FUNCTIONAL MATERIALS. |
| MLA | Liu, Bo,et al."Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect.".ADVANCED FUNCTIONAL MATERIALS (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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