Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis
文献类型：期刊论文
| 作者 | Zhai, Xinyun; Hou, Chunyong; Pan, Haobo; Lu, William Weijia; Liu, Wenguang; Ruan, Changshun |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In this work, a biodegradable and biocompatible nanocomposite hydrogel was successfully prepared on basis of nanoclay and polyethylene-glycol diacrylates (PEGDA). The physical interspersing between nanoclay particles and PEG chains combined with the chemical crosslinking within the PEG networks endowed the obtained nanocomposite hydrogels with enhanced mechanical properties in comparison with pure PEG hydrogels. Simultaneously, the incorporation of nanoclay to the PEGDA/ nanoclay (PEGDA-Clay) nanocomposite hydrogel not only improved the adsorption and spreading ability of cells on the hydrogels, but also effectively facilitated the in vitro osteogenic differentiation of primary rat osteoblasts due to the sustainable release of magnesium ions (Mg2+) and silicon ions (Si4+) from the PEGDA-Clay nanocomposite hydrogel. In addition, the implantation of the PEGDA-Clay nanocomposite hydrogels in the tibia defects of Sprague-Dawley rat could promoted the new bone formation efficiently, further suggesting the excellent osteogenic ability of PEGDA-Clay nanocomposite hydrogel. We expect that this kind of biocompatible nanocomposite hydrogels with attractive mechanical properties and a variety of bioactive osteogenic ions will offer a new possibility for bone tissue regeneration. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14723]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Zhai, Xinyun,Hou, Chunyong,Pan, Haobo,et al. Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018. |
| APA | Zhai, Xinyun,Hou, Chunyong,Pan, Haobo,Lu, William Weijia,Liu, Wenguang,&Ruan, Changshun.(2018).Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY. |
| MLA | Zhai, Xinyun,et al."Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。