Oxygen-Boosted Immunogenic Photodynamic Therapy Based on Gold Nanocages@MnO2 to Inhibit Tumor Growth and Metastases
文献类型：会议论文
| 作者 | Huaqing Chen; Lintao Cai; Yifan Ma; Mingbing Zheng; Ze Chen; Zhikuan Chen; Huamei He; Lanlan Liu; Ruijing Liang |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | 上海 |
| 英文摘要 | Photodynamic therapy (PDT) is an important strategy to eliminate the primary tumor, however, its therapeutic efficacy against metastases and recurrence is still limited. Here, we develop the core-shell gold nanocage@manganese dioxide (AuNC@MnO2, AM) nanoparticles as tumor microenvironment responsive oxygen producers for oxygen-boosted immunogenic PDT. In this platform, MnO2 shell degrades in mild acidic/H2O2 condition and generates massive oxygen to boost PDT effect of AM nanoparticles under laser irradiation. Fluorescence (FL)/photoacoustic (PA)/magnetic resonance (MR) multimodal imaging confirms the effective accumulation of AM nanoparticles with sufficient oxygenation in tumor site to ameliorate local hypoxia. Moreover, the oxygen-boosted PDT effect of AM not only destroys primary tumor effectively, but also elicits immunogenic cell death (ICD) with damage-associated molecular patterns (DAMPs) release, which subsequently induces dendritic cells (DCs) maturation and effector cells activation, thereby robustly evoking systematic antitumor immune responses against metastases. Hence, this oxygen-boosted PDT nanosystem offers a promising approach to ablate primary tumor and simultaneously prevent tumor metastases via immunogenic abscopal effects. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14744]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Huaqing Chen,Lintao Cai,Yifan Ma,et al. Oxygen-Boosted Immunogenic Photodynamic Therapy Based on Gold Nanocages@MnO2 to Inhibit Tumor Growth and Metastases[C]. 见:. 上海. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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