Targeted Co-Delivery of Zinc Protoporphyrin IX and Adjuvant to Reprogramme Tumor-Associated Macrophages for Effective Cancer Immunotherapy
文献类型：会议论文
| 作者 | Haimei Zhou; Ruijing Liang; Lintao Cai; Zhikuan Chen; Lanlan Liu; Huamei He |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | 上海 |
| 英文摘要 | Immunosuppressive tumor-associated macrophages (TAMs) are potential targets for cancer immunotherapy.[1,2] However, TAMs dysfunction and their poor responsiveness to toll-like receptor (TLR) stimulation are major challenges for achieving successful cancer immunotherapy. The present study developed self-assembled galactose-functionalized poly(L-lysine)-b-poly(ethyleneglycol) (LEG) polypeptide nanoparticles to TAMs-targeted co-deliver heme oxygenase-1 (HO-1) inhibitor Zinc protoporphyrin IX (ZnPP) and adjuvant, which aimed to re-polarize TAMs to M1 macrophages in vivo. The study showed that aberrantly depressed reactive oxygen species (ROS) in bone marrow-derived TAMs (BM-TAMs) abolished polyinosinic-polycytidylic acid (Poly I:C, PIC)-induced TAMs re-polarization through increasing STAT3 gene. The ZnPP and PIC loaded LEG (ZnPP-LEG/P) facilitated the targeted co-delivery of ZnPP and PIC to macrophage to increase the level of ROS and decrease STAT3 in BM-TAMs, thereby recovering their sensitivity to PIC stimulation. Then, ZnPP-LEG/P effectively repolarized immunosuppressive TAMs to anti-tumor M1 macrophages through elevating M1 macrophage markers (IL-12, iNOS and CD86) and suppressing M2 macrophage markers (Msr2 and Arg1) in TAMs. Moreover, ZnPP-LEG/P significantly increased activated T lymphocytes and NK cells in tumors, which consequently led to robust tumor regression. Hence, TAM-targeted delivery of ZnPP and adjuvant with LEG nanovectors could be a promising approach to re-polarize TAMs to M1 macrophages in situ for effective cancer immunotherapy. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14749]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Haimei Zhou,Ruijing Liang,Lintao Cai,et al. Targeted Co-Delivery of Zinc Protoporphyrin IX and Adjuvant to Reprogramme Tumor-Associated Macrophages for Effective Cancer Immunotherapy[C]. 见:. 上海. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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