Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect
文献类型：会议论文
| 作者 | Haimei Zhou; Mingbin Zheng; Lintao Cai; Zhikuan Chen; Ruijing Liang; Huamei He; Lanlan Liu |
| 出版日期 | 2018 |
| 会议日期 | 2018 |
| 会议地点 | 上海 |
| 英文摘要 | An ideal cancer therapeutic strategy is expected to possess potent ability that not only can ablate the primary tumor, but also can prevent the distance metastasis and relapse [1]. Herein, chlorine e6 (Ce6) loaded human serum albumin (HSA)/hemoglobin (Hb) hybrid protein oxygen nanocarrier (C@HPOC) were developed via intermolecular disulfide conjugation to apply as oxygen self-sufficient nanophotosensitizers [2]. Benefited from the HSA-targeting delivery of oxygen and photosensitizer [3], C@HPOC not only relieved tumor hypoxia and produced massive reactive oxygen species (ROS) under laser irradiation to boost the PDT efficacy, but also elicited immunogenic cell death (ICD) with danger-associated molecular patterns (DAMPs) release to promote the maturation of dendritic cells (DCs) and subsequent activation of T lymphocytes and natural killer cells. Our results revealed that C@HPOC-mediated immunogenic PDT can directly destroy the primary tumors, and further suppress the distant tumors and prevent the lung metastasis in a metastatic triple-negative breast cancer (TNBC) model by stimulating strong and systemic anti-tumor immune responses. This study provides a new paradigm of oxygen-augmented immunogenic PDT for advanced or metastatic TNBC treatment. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/14750]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 推荐引用方式 GB/T 7714 | Haimei Zhou,Mingbin Zheng,Lintao Cai,et al. Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect[C]. 见:. 上海. 2018. |
入库方式： OAI收割
来源：深圳先进技术研究院
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